The liver in rocky mountain spotted fever

J. S. Adams, David Walker

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Hepatic tissues from nine patients who had fatal Rocky Mountain spotted fever were examined in sequential sections by brightfield and immunofluorescence microscopy for histologic lesions and for coincidence of these lesions with the distribution of Rickettsia rickettsii. The basic hepatic lesion in Rocky Mountain spotted fever is an inflammation of the portal triad in which large mononuclear cells and neutrophils predominate. Rickettsiae were demonstrated in lesions of the portal triads in eight of nine cases. Inflammation of the portal triad and sinusoidal erythrophagocytosis showed a strong relationship to the presence of the disease state when comparisons with age- and sex-matched control subjects were made. Hepatocellular necrosis was not found to be an important pathologic feature of the disease. Elevated serum bilirubin values and jaundice are likely to be due to a combination of duct obstruction secondary to inflammation and edema of portal triads, and hemolysis.

Original languageEnglish (US)
Pages (from-to)156-161
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume75
Issue number2
StatePublished - 1981
Externally publishedYes

Fingerprint

Rocky Mountain Spotted Fever
Inflammation
Liver
Rickettsia rickettsii
Rickettsia
Hemolysis
Jaundice
Fluorescence Microscopy
Bilirubin
Edema
Neutrophils
Necrosis
Serum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The liver in rocky mountain spotted fever. / Adams, J. S.; Walker, David.

In: American Journal of Clinical Pathology, Vol. 75, No. 2, 1981, p. 156-161.

Research output: Contribution to journalArticle

@article{eb2f2338b4bc4756b45ac919c47cdbb5,
title = "The liver in rocky mountain spotted fever",
abstract = "Hepatic tissues from nine patients who had fatal Rocky Mountain spotted fever were examined in sequential sections by brightfield and immunofluorescence microscopy for histologic lesions and for coincidence of these lesions with the distribution of Rickettsia rickettsii. The basic hepatic lesion in Rocky Mountain spotted fever is an inflammation of the portal triad in which large mononuclear cells and neutrophils predominate. Rickettsiae were demonstrated in lesions of the portal triads in eight of nine cases. Inflammation of the portal triad and sinusoidal erythrophagocytosis showed a strong relationship to the presence of the disease state when comparisons with age- and sex-matched control subjects were made. Hepatocellular necrosis was not found to be an important pathologic feature of the disease. Elevated serum bilirubin values and jaundice are likely to be due to a combination of duct obstruction secondary to inflammation and edema of portal triads, and hemolysis.",
author = "Adams, {J. S.} and David Walker",
year = "1981",
language = "English (US)",
volume = "75",
pages = "156--161",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "2",

}

TY - JOUR

T1 - The liver in rocky mountain spotted fever

AU - Adams, J. S.

AU - Walker, David

PY - 1981

Y1 - 1981

N2 - Hepatic tissues from nine patients who had fatal Rocky Mountain spotted fever were examined in sequential sections by brightfield and immunofluorescence microscopy for histologic lesions and for coincidence of these lesions with the distribution of Rickettsia rickettsii. The basic hepatic lesion in Rocky Mountain spotted fever is an inflammation of the portal triad in which large mononuclear cells and neutrophils predominate. Rickettsiae were demonstrated in lesions of the portal triads in eight of nine cases. Inflammation of the portal triad and sinusoidal erythrophagocytosis showed a strong relationship to the presence of the disease state when comparisons with age- and sex-matched control subjects were made. Hepatocellular necrosis was not found to be an important pathologic feature of the disease. Elevated serum bilirubin values and jaundice are likely to be due to a combination of duct obstruction secondary to inflammation and edema of portal triads, and hemolysis.

AB - Hepatic tissues from nine patients who had fatal Rocky Mountain spotted fever were examined in sequential sections by brightfield and immunofluorescence microscopy for histologic lesions and for coincidence of these lesions with the distribution of Rickettsia rickettsii. The basic hepatic lesion in Rocky Mountain spotted fever is an inflammation of the portal triad in which large mononuclear cells and neutrophils predominate. Rickettsiae were demonstrated in lesions of the portal triads in eight of nine cases. Inflammation of the portal triad and sinusoidal erythrophagocytosis showed a strong relationship to the presence of the disease state when comparisons with age- and sex-matched control subjects were made. Hepatocellular necrosis was not found to be an important pathologic feature of the disease. Elevated serum bilirubin values and jaundice are likely to be due to a combination of duct obstruction secondary to inflammation and edema of portal triads, and hemolysis.

UR - http://www.scopus.com/inward/record.url?scp=0019434922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019434922&partnerID=8YFLogxK

M3 - Article

VL - 75

SP - 156

EP - 161

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 2

ER -