The localization of 5 hydroxytryptamine in chromaffin cells of the leech body wall

R. E. Coggeshall, B. A. Yaksta Sauerland

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The present study is an analysis of the sites of uptake of radioactive 5 hydroxytryptamine (5 HT) into the leech body wall. Two sites of uptake are noted: the axons and nerve terminals containing large dense core vesicles and the type I cells of the vasofibrous tissue. Both of these cell types are chromaffin cells in that they contain vesicles or granules with cores that reduce dichromate salts. Chemical analysis indicates that most of the radioactivity in the body wall at the time of sacrifice is 5 HT. Thus, these two cell types acquire 5 HT when it is present in the extracellular environment and presumably store it in the cores of the vesicles or granules that characterize these cells. This acquisition of 5 HT may be an important method of inactivation for 5 HT. In addition, the fine structure of the vasofibrous tissues is described here for the first time. There are two types of cells in the vasofibrous tissue, rather than one as previously thought, and the electron microscope clearly shows that the fibrils of vasofibrous tissue are not pigmented capillaries.

Original languageEnglish (US)
Pages (from-to)459-470
Number of pages12
JournalJournal of Comparative Neurology
Volume156
Issue number4
StatePublished - 1974

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Leeches
Chromaffin Cells
Serotonin
Presynaptic Terminals
Secretory Vesicles
Radioactivity
Salts
Cell Body
Electrons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The localization of 5 hydroxytryptamine in chromaffin cells of the leech body wall. / Coggeshall, R. E.; Yaksta Sauerland, B. A.

In: Journal of Comparative Neurology, Vol. 156, No. 4, 1974, p. 459-470.

Research output: Contribution to journalArticle

Coggeshall, RE & Yaksta Sauerland, BA 1974, 'The localization of 5 hydroxytryptamine in chromaffin cells of the leech body wall', Journal of Comparative Neurology, vol. 156, no. 4, pp. 459-470.
Coggeshall, R. E. ; Yaksta Sauerland, B. A. / The localization of 5 hydroxytryptamine in chromaffin cells of the leech body wall. In: Journal of Comparative Neurology. 1974 ; Vol. 156, No. 4. pp. 459-470.
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