The long-latency component of cerebral evoked potentials in anesthetized cats

K. H. Lee, J. Kim, Jin Chung

Research output: Contribution to journalArticle

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Abstract

A late component of the cortical evoked potential elicited by somatosensory afferent input was studied in cats anesthetized with α-chloralose. Cortical evoked potentials were recorded from the somatosensory-motor cortex during stimulation of the sural nerve with graded intensities. The stimulus intensity was adjusted to activate Aαβ fibers only, then both Aαβ and Aδ fibers, and both A and C fibers, as judged by afferent volleys monitored from the sural nerve proximal to the stimulating site. In addition to early components reported previously, a very late component was identified at a latency of 400 to 600 msec following stimulation of the sural nerve with intensities above threshold for Aδ fibers. A further increase in stimulation intensity to include activation of C fibers did not reveal any more components. This late component was depressed by a systemic intravenous injection of morphine (2 mg/kg), and intravenous naloxone (0.1 mg/kg) reversed the effect of morphine. The late component of the evoked potential could also be recorded from subcortical tissue after decortication of the sensorimotor cortex. From these results, it appears that a very late component of the cortical evoked potential can be recorded from cats anesthetized with α-chloralose. The late component is evoked by activation of peripheral Aδ fibers. Furthermore, its morphine sensitivity suggests that this component may be elicited by nociceptive afferent fibers. If further investigations prove this, the late component, which is analogous to human long-latency potentials, could be used in an experimental model for pain research

Original languageEnglish (US)
Pages (from-to)392-397
Number of pages6
JournalJournal of Neurosurgery
Volume65
Issue number3
StatePublished - 1986

Fingerprint

Myelinated Nerve Fibers
Evoked Potentials
Cats
Sural Nerve
Morphine
Unmyelinated Nerve Fibers
Chloralose
Somatosensory Cortex
Somatosensory Evoked Potentials
Motor Cortex
Naloxone
Intravenous Injections
Theoretical Models
Pain
Research

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

The long-latency component of cerebral evoked potentials in anesthetized cats. / Lee, K. H.; Kim, J.; Chung, Jin.

In: Journal of Neurosurgery, Vol. 65, No. 3, 1986, p. 392-397.

Research output: Contribution to journalArticle

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