The Long-Term Effect of Oxandrolone on Hepatic Acute Phase Proteins in Severely Burned Children

Suchmor Thomas, Steven Wolf, Kevin D. Murphy, David L. Chinkes, David Herndon, Basil A. Pruitt, Nabil Atweh

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background: Acute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins. Methods: Thirty-five children with ≥40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mouth twice daily) from postoperative day 5 to 1 year postburn. Levels of constitutive proteins and acute phase proteins were measured at admission; at discharge; and at 6, 9, and 12 months after burn. Total albumin supplementation and hepatic transaminases were also assessed. RESULTS: Constitutive proteins such as albumin, prealbumin, and retinol-binding protein levels increased (p < 0.05), and acute phase proteins such as α1-acid glycoprotein, C3 complement, α2-macroglobulin, and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo (p < 0.05). Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group. Hepatic transaminases remained within normal levels. CONCLUSION. Treatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume56
Issue number1
StatePublished - Jan 2004

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Keywords

  • α-Acid glycoprotein
  • α-Macroglobulin
  • Acute phase proteins
  • Albumin
  • C-reactive protein
  • C3 complement
  • Constitutive proteins
  • Haptoglobin
  • Oxandrolone
  • Prealbumin
  • Retinol-binding protein
  • Severe burns
  • Transferrin

ASJC Scopus subject areas

  • Surgery

Cite this

Thomas, S., Wolf, S., Murphy, K. D., Chinkes, D. L., Herndon, D., Pruitt, B. A., & Atweh, N. (2004). The Long-Term Effect of Oxandrolone on Hepatic Acute Phase Proteins in Severely Burned Children. Journal of Trauma - Injury, Infection and Critical Care, 56(1), 37-44.