The low-density lipoprotein receptor

Ligands, debates and lore

Gabrielle Rudenko, Johann Deisenhofer

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Like pieces belonging to a large mosaic, the structures of low-density lipoprotein receptor (LDL-R) modules have been elucidated one by one in recent years. LDL-Rs localized on hepatocytes play an important role in removing cholesterol-transporting LDL particles from the plasma by receptor-mediated endocytosis. Key steps in this process involve the LDL-R binding LDL at neutral pH at the cell surface and, after internalization, releasing it again at acidic pH in the endosomes. How the modules of the LDL-R might interact within the intact receptor to carry out ligand binding and release has been revealed by the recent crystal structure of the extracellular domain of the LDL-R.

Original languageEnglish (US)
Pages (from-to)683-689
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume13
Issue number6
DOIs
StatePublished - Dec 2003
Externally publishedYes

Fingerprint

LDL Receptors
Ligands
Endosomes
Endocytosis
LDL Cholesterol
Hepatocytes
oxidized low density lipoprotein

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

The low-density lipoprotein receptor : Ligands, debates and lore. / Rudenko, Gabrielle; Deisenhofer, Johann.

In: Current Opinion in Structural Biology, Vol. 13, No. 6, 12.2003, p. 683-689.

Research output: Contribution to journalArticle

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