The medical treatment for autoimmune hepatitis through corticosteroid to new immunosuppressive agents: A concise review

Roger D. Soloway, Alexander T. Hewlett

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The treatment of autoimmune hepatitis is evolving as the natural history of the disease and newer agents become available. This concise review will outline the various treatment options in these patients. Treatment with current corticosteroids and azathioprine works in most patients but issues of intolerance and incomplete response arise. These situations led to the investigation of newer immunosupressants including mycophenolate mofetil, budesonide cyclosporine, tacrolimus and ursodeoxycholic acid. The newer agents have been studied in small patient numbers so they are not first-line treatment yet but do have a clear role in those patients with intolerance of incomplete response to standard corticosteroids and azathioprine.

Original languageEnglish (US)
Pages (from-to)204-207
Number of pages4
JournalAnnals of Hepatology
Volume6
Issue number4
StatePublished - Oct 2007

Fingerprint

Autoimmune Hepatitis
Immunosuppressive Agents
Adrenal Cortex Hormones
Azathioprine
Mycophenolic Acid
Ursodeoxycholic Acid
Budesonide
Tacrolimus
Therapeutics
Cyclosporine

Keywords

  • Azathioprine
  • Mycophenolate mofetil
  • Remission
  • Ursodeoxycholic acid

ASJC Scopus subject areas

  • Hepatology

Cite this

The medical treatment for autoimmune hepatitis through corticosteroid to new immunosuppressive agents : A concise review. / Soloway, Roger D.; Hewlett, Alexander T.

In: Annals of Hepatology, Vol. 6, No. 4, 10.2007, p. 204-207.

Research output: Contribution to journalArticle

@article{1c2ca1cf4e50413fafe7f8c60565c62c,
title = "The medical treatment for autoimmune hepatitis through corticosteroid to new immunosuppressive agents: A concise review",
abstract = "The treatment of autoimmune hepatitis is evolving as the natural history of the disease and newer agents become available. This concise review will outline the various treatment options in these patients. Treatment with current corticosteroids and azathioprine works in most patients but issues of intolerance and incomplete response arise. These situations led to the investigation of newer immunosupressants including mycophenolate mofetil, budesonide cyclosporine, tacrolimus and ursodeoxycholic acid. The newer agents have been studied in small patient numbers so they are not first-line treatment yet but do have a clear role in those patients with intolerance of incomplete response to standard corticosteroids and azathioprine.",
keywords = "Azathioprine, Mycophenolate mofetil, Remission, Ursodeoxycholic acid",
author = "Soloway, {Roger D.} and Hewlett, {Alexander T.}",
year = "2007",
month = "10",
language = "English (US)",
volume = "6",
pages = "204--207",
journal = "Annals of Hepatology",
issn = "1665-2681",
publisher = "Mexican Association of Hepatology",
number = "4",

}

TY - JOUR

T1 - The medical treatment for autoimmune hepatitis through corticosteroid to new immunosuppressive agents

T2 - A concise review

AU - Soloway, Roger D.

AU - Hewlett, Alexander T.

PY - 2007/10

Y1 - 2007/10

N2 - The treatment of autoimmune hepatitis is evolving as the natural history of the disease and newer agents become available. This concise review will outline the various treatment options in these patients. Treatment with current corticosteroids and azathioprine works in most patients but issues of intolerance and incomplete response arise. These situations led to the investigation of newer immunosupressants including mycophenolate mofetil, budesonide cyclosporine, tacrolimus and ursodeoxycholic acid. The newer agents have been studied in small patient numbers so they are not first-line treatment yet but do have a clear role in those patients with intolerance of incomplete response to standard corticosteroids and azathioprine.

AB - The treatment of autoimmune hepatitis is evolving as the natural history of the disease and newer agents become available. This concise review will outline the various treatment options in these patients. Treatment with current corticosteroids and azathioprine works in most patients but issues of intolerance and incomplete response arise. These situations led to the investigation of newer immunosupressants including mycophenolate mofetil, budesonide cyclosporine, tacrolimus and ursodeoxycholic acid. The newer agents have been studied in small patient numbers so they are not first-line treatment yet but do have a clear role in those patients with intolerance of incomplete response to standard corticosteroids and azathioprine.

KW - Azathioprine

KW - Mycophenolate mofetil

KW - Remission

KW - Ursodeoxycholic acid

UR - http://www.scopus.com/inward/record.url?scp=37549014513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37549014513&partnerID=8YFLogxK

M3 - Article

C2 - 18007548

AN - SCOPUS:37549014513

VL - 6

SP - 204

EP - 207

JO - Annals of Hepatology

JF - Annals of Hepatology

SN - 1665-2681

IS - 4

ER -