The multiple roles of sGP in Ebola pathogenesis

Marc Antoine De La Vega, Gary Wong, Gary P. Kobinger, Xiangguo Qiu

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Ebola causes severe hemorrhagic fever in humans and nonhuman primates, and there are currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) may be partially attributed to the secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. sGP is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalViral Immunology
Volume28
Issue number1
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

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