The multiple roles of sGP in Ebola pathogenesis

Marc Antoine De La Vega; Gary Wong; Gary P. Kobinger; Xiangguo Qiu

doi:10.1089/vim.2014.0068

The multiple roles of sGP in Ebola pathogenesis

Marc Antoine De La Vega, Gary Wong, Gary P. Kobinger, Xiangguo Qiu

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Ebola causes severe hemorrhagic fever in humans and nonhuman primates, and there are currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) may be partially attributed to the secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. sGP is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments.

Original language	English (US)
Pages (from-to)	3-9
Number of pages	7
Journal	Viral Immunology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1089/vim.2014.0068
State	Published - Feb 1 2015
Externally published	Yes

ASJC Scopus subject areas

Immunology
Molecular Medicine
Virology

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10.1089/vim.2014.0068

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AB - Ebola causes severe hemorrhagic fever in humans and nonhuman primates, and there are currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) may be partially attributed to the secreted glycoprotein (sGP), which is the main product transcribed from its GP gene. sGP is secreted from infected cells and can be readily detected in the serum of EBOV-infected hosts. This review summarizes the multiple roles that sGP may play during infection and highlights the implications for the future design of vaccines and treatments.

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The multiple roles of sGP in Ebola pathogenesis

Abstract

ASJC Scopus subject areas

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