The nitric oxide pathway in pre-eclampsia

Pathophysiological implications

Irina A. Buhimschi, George Saade, Kristof Chwalisz, Robert E. Garfield

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Pre-eclampsia, one of the most significant health problems in human pregnancy, complicates ~ 6-8% of all gestations and is the leading cause of fetal growth retardation, infant morbidity and mortality, premature birth and maternal death. Recent research implicates free radicals in the pathophysiology of pre-eclampsia. This review covers the biochemistry of nitric oxide (NO) and possible interactions with other free radicals. Studies in the rat show that pregnancy is associated with enhanced production and responsiveness to NO in both reproductive tissues and blood vessels. Rats infused with N(G)-nitro-L-arginine methyl ester (L-NAME, a NO synthase inhibitor) have been used as an animal model of pre-eclampsia, and the effects of steroid hormones on blood pressure in this model have been tested. Results suggest that pre-eclampsia may be a state of NO deficiency. However, in humans there seem to be contradictions regarding the involvement of NO in maternal adaptation to pregnancy. It is suggested that NO may be one of several systems that act in concert to maintain a symbiotic relationship between mother and fetus. However, the input of each system may be genetically determined.

Original languageEnglish (US)
Pages (from-to)25-42
Number of pages18
JournalHuman Reproduction Update
Volume4
Issue number1
DOIs
StatePublished - Jan 1998

Fingerprint

Pre-Eclampsia
Nitric Oxide
Pregnancy
NG-Nitroarginine Methyl Ester
Free Radicals
Maternal-Fetal Relations
Maternal Death
Premature Mortality
Fetal Growth Retardation
Premature Birth
Infant Mortality
Nitric Oxide Synthase
Biochemistry
Blood Vessels
Animal Models
Steroids
Mothers
Hormones
Blood Pressure
Morbidity

Keywords

  • Endothelium-derived relaxing factor
  • Hypertension
  • Pregnancy
  • Superoxide
  • Toxaemia

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

The nitric oxide pathway in pre-eclampsia : Pathophysiological implications. / Buhimschi, Irina A.; Saade, George; Chwalisz, Kristof; Garfield, Robert E.

In: Human Reproduction Update, Vol. 4, No. 1, 01.1998, p. 25-42.

Research output: Contribution to journalArticle

Buhimschi, Irina A. ; Saade, George ; Chwalisz, Kristof ; Garfield, Robert E. / The nitric oxide pathway in pre-eclampsia : Pathophysiological implications. In: Human Reproduction Update. 1998 ; Vol. 4, No. 1. pp. 25-42.
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