The NLRP3 Inflammasome and Its Role in Sepsis Development

Lucinéia Gainski Danielski; Amanda Della Giustina; Sandra Bonfante; Tatiana Barichello; Fabricia Petronilho

doi:10.1007/s10753-019-01124-9

The NLRP3 Inflammasome and Its Role in Sepsis Development

Lucinéia Gainski Danielski
, Amanda Della Giustina
, Sandra Bonfante
, Tatiana Barichello
, Fabricia Petronilho

Research output: Contribution to journal › Review article › peer-review

207 Scopus citations

Abstract

The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor.

Original language	English (US)
Pages (from-to)	24-31
Number of pages	8
Journal	Inflammation
Volume	43
Issue number	1
DOIs	https://doi.org/10.1007/s10753-019-01124-9
State	Published - Feb 1 2020
Externally published	Yes

Keywords

inflammasome
NLRP3
organ failure
sepsis

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1007/s10753-019-01124-9

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abstract = "The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor.",

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AU - Petronilho, Fabricia

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N2 - The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor.

AB - The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor.

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KW - organ failure

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The NLRP3 Inflammasome and Its Role in Sepsis Development

Abstract

Keywords

ASJC Scopus subject areas

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