The nuclear factor-B-interleukin-6 signalling pathway mediating vascular inflammation

Allan R. Brasier

Research output: Contribution to journalArticle

222 Citations (Scopus)

Abstract

Vascular inflammation is a common pathophysiological response to diverse cardiovascular disease processes, including atherosclerosis, myocardial infarction, congestive heart failure, and aortic aneurysms/dissection. Inflammation is an ordered process initiated by vascular injury that produces enhanced leucocyte adherence, chemotaxis, and finally activation in situ. This process is coordinated by local secretion of adhesion molecules, chemotactic factors, and cytokines whose expression is the result of vascular injury-induced signal transduction networks. A wide variety of mediators of the vascular injury response have been identified; these factors include vasoactive peptides (angiotensin II, Ang II), CD40 ligands, oxidized cholesterol, and advanced glycation end-products. Downstream, the nuclear factor-B (NF-B) transcription factor performs an important signal integration step, responding to mediators of vascular injury in a stimulus-dependent and cell type-specific manner. The ultimate consequence of NF-B signalling is the activation of inflammatory genes including adhesion molecules and chemotaxins. However, clinically, the hallmark of vascular NF-B activation is the production of interleukin-6 (IL-6), whose local role in vascular inflammation is relatively unknown. The recent elucidation for the role of the IL-6 signalling pathway in Ang II-induced vascular inflammation as one that controls monocyte activation as well as its diverse signalling mechanism will be reviewed. These new discoveries further our understanding for the important role of the NF-B-IL-6 signalling pathway in the process of vascular inflammation.

Original languageEnglish (US)
Pages (from-to)211-218
Number of pages8
JournalCardiovascular Research
Volume86
Issue number2
DOIs
StatePublished - May 2010

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CCAAT-Enhancer-Binding Protein-beta
Vascular System Injuries
Blood Vessels
Inflammation
Chemotactic Factors
Angiotensin II
Interleukin-6
Heart Aneurysm
Leukocyte Chemotaxis
CD40 Ligand
Advanced Glycosylation End Products
Aortic Aneurysm
Chemokines
Transcriptional Activation
Dissection
Monocytes
Signal Transduction
Atherosclerosis
Transcription Factors
Cardiovascular Diseases

Keywords

  • Angiotensin II
  • Interleukin-6
  • Nuclear factor-B
  • Signal transducer and activator of transcription 3

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

Cite this

The nuclear factor-B-interleukin-6 signalling pathway mediating vascular inflammation. / Brasier, Allan R.

In: Cardiovascular Research, Vol. 86, No. 2, 05.2010, p. 211-218.

Research output: Contribution to journalArticle

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