The Origin of COVID-19 and Why It Matters

David M. Morens, Joel G. Breman, Charles H. Calisher, Peter C. Doherty, Beatrice H. Hahn, Gerald T. Keusch, Laura D. Kramer, James W. LeDuc, Thomas P. Monath, Jeffery K. Taubenberger

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

The COVID-19 pandemic is among the deadliest infectious diseases to have emerged in recent history. As with all past pandemics, the specific mechanism of its emergence in humans remains unknown. Nevertheless, a large body of virologic, epidemiologic, veterinary, and ecologic data establishes that the new virus, SARS-CoV-2, evolved directly or indirectly from a β-coronavirus in the sarbecovirus (SARS-like virus) group that naturally infect bats and pangolins in Asia and Southeast Asia. Scientists have warned for decades that such sarbecoviruses are poised to emerge again and again, identified risk factors, and argued for enhanced pandemic prevention and control efforts. Unfortunately, few such preventive actions were taken resulting in the latest coronavirus emergence detected in late 2019 which quickly spread pandemically. The risk of similar coronavirus outbreaks in the future remains high. In addition to controlling the COVID-19 pandemic, we must undertake vigorous scientific, public health, and societal actions, including significantly increased funding for basic and applied research addressing disease emergence, to prevent this tragic history from repeating itself.

Original languageEnglish (US)
Pages (from-to)955-959
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume103
Issue number3
DOIs
StatePublished - Sep 2020

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Morens, D. M., Breman, J. G., Calisher, C. H., Doherty, P. C., Hahn, B. H., Keusch, G. T., Kramer, L. D., LeDuc, J. W., Monath, T. P., & Taubenberger, J. K. (2020). The Origin of COVID-19 and Why It Matters. American Journal of Tropical Medicine and Hygiene, 103(3), 955-959. https://doi.org/10.4269/ajtmh.20-0849