The P50 Research Center in Perioperative Sciences: How the investment by the National Institute of General Medical Sciences in Team Science has reduced post-burn mortality

Celeste Finnerty, Karel Capek, Charles Voigt, Gabriel Hundeshagen, Janos Cambiaso-Daniel, Craig Porter, Linda Sousse, Amina El Ayadi, Ramon Zapata Sirvent, Ashley Guillory, Oscar Suman, David Herndon

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1 Citation (Scopus)

Abstract

ABSTRACT: Since the inception of the P50 Research Center in Peri-Operative Sciences (RCIPS) funding mechanism, the National Institute for General Medical Sciences has supported a team approach to science. Many advances in critical care, particularly burns, have been driven by RCIPS teams. In fact, burns that were fatal in the early 1970s, prior to the inception of the P50 RCIPS program, are now routinely survived as a result of the P50-funded research. The advances in clinical care that led to the reduction in post-burn death were made by optimizing resuscitation, incorporating early excision and grafting, bolstering acute care including support for inhalation injury, modulating the hypermetabolic response, augmenting the immune response, incorporating aerobic exercise, and developing anti-scarring strategies. The work of the Burn RCIPS programs advanced our understanding of the pathophysiological response to burn injury. As a result, the effects of a large burn on all organ systems have been studied, leading to the discovery of persistent dysfunction, elucidation of the underlying molecular mechanisms, and identification of potential therapeutic targets. Survival and subsequent patient satisfaction with quality of life have increased. In this review article, we describe the contributions of the Galveston P50 RCIPS that have changed post-burn care and have considerably reduced post-burn mortality.

Original languageEnglish (US)
JournalJournal of Trauma and Acute Care Surgery
DOIs
StateAccepted/In press - Jul 8 2017

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National Institute of General Medical Sciences (U.S.)
Burns
Mortality
Research
Burn Units
Wounds and Injuries
Critical Care
Patient Satisfaction
Resuscitation
Inhalation
Cicatrix
Quality of Life
Exercise

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

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title = "The P50 Research Center in Perioperative Sciences: How the investment by the National Institute of General Medical Sciences in Team Science has reduced post-burn mortality",
abstract = "ABSTRACT: Since the inception of the P50 Research Center in Peri-Operative Sciences (RCIPS) funding mechanism, the National Institute for General Medical Sciences has supported a team approach to science. Many advances in critical care, particularly burns, have been driven by RCIPS teams. In fact, burns that were fatal in the early 1970s, prior to the inception of the P50 RCIPS program, are now routinely survived as a result of the P50-funded research. The advances in clinical care that led to the reduction in post-burn death were made by optimizing resuscitation, incorporating early excision and grafting, bolstering acute care including support for inhalation injury, modulating the hypermetabolic response, augmenting the immune response, incorporating aerobic exercise, and developing anti-scarring strategies. The work of the Burn RCIPS programs advanced our understanding of the pathophysiological response to burn injury. As a result, the effects of a large burn on all organ systems have been studied, leading to the discovery of persistent dysfunction, elucidation of the underlying molecular mechanisms, and identification of potential therapeutic targets. Survival and subsequent patient satisfaction with quality of life have increased. In this review article, we describe the contributions of the Galveston P50 RCIPS that have changed post-burn care and have considerably reduced post-burn mortality.",
author = "Celeste Finnerty and Karel Capek and Charles Voigt and Gabriel Hundeshagen and Janos Cambiaso-Daniel and Craig Porter and Linda Sousse and {El Ayadi}, Amina and {Zapata Sirvent}, Ramon and Ashley Guillory and Oscar Suman and David Herndon",
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T2 - How the investment by the National Institute of General Medical Sciences in Team Science has reduced post-burn mortality

AU - Finnerty, Celeste

AU - Capek, Karel

AU - Voigt, Charles

AU - Hundeshagen, Gabriel

AU - Cambiaso-Daniel, Janos

AU - Porter, Craig

AU - Sousse, Linda

AU - El Ayadi, Amina

AU - Zapata Sirvent, Ramon

AU - Guillory, Ashley

AU - Suman, Oscar

AU - Herndon, David

PY - 2017/7/8

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N2 - ABSTRACT: Since the inception of the P50 Research Center in Peri-Operative Sciences (RCIPS) funding mechanism, the National Institute for General Medical Sciences has supported a team approach to science. Many advances in critical care, particularly burns, have been driven by RCIPS teams. In fact, burns that were fatal in the early 1970s, prior to the inception of the P50 RCIPS program, are now routinely survived as a result of the P50-funded research. The advances in clinical care that led to the reduction in post-burn death were made by optimizing resuscitation, incorporating early excision and grafting, bolstering acute care including support for inhalation injury, modulating the hypermetabolic response, augmenting the immune response, incorporating aerobic exercise, and developing anti-scarring strategies. The work of the Burn RCIPS programs advanced our understanding of the pathophysiological response to burn injury. As a result, the effects of a large burn on all organ systems have been studied, leading to the discovery of persistent dysfunction, elucidation of the underlying molecular mechanisms, and identification of potential therapeutic targets. Survival and subsequent patient satisfaction with quality of life have increased. In this review article, we describe the contributions of the Galveston P50 RCIPS that have changed post-burn care and have considerably reduced post-burn mortality.

AB - ABSTRACT: Since the inception of the P50 Research Center in Peri-Operative Sciences (RCIPS) funding mechanism, the National Institute for General Medical Sciences has supported a team approach to science. Many advances in critical care, particularly burns, have been driven by RCIPS teams. In fact, burns that were fatal in the early 1970s, prior to the inception of the P50 RCIPS program, are now routinely survived as a result of the P50-funded research. The advances in clinical care that led to the reduction in post-burn death were made by optimizing resuscitation, incorporating early excision and grafting, bolstering acute care including support for inhalation injury, modulating the hypermetabolic response, augmenting the immune response, incorporating aerobic exercise, and developing anti-scarring strategies. The work of the Burn RCIPS programs advanced our understanding of the pathophysiological response to burn injury. As a result, the effects of a large burn on all organ systems have been studied, leading to the discovery of persistent dysfunction, elucidation of the underlying molecular mechanisms, and identification of potential therapeutic targets. Survival and subsequent patient satisfaction with quality of life have increased. In this review article, we describe the contributions of the Galveston P50 RCIPS that have changed post-burn care and have considerably reduced post-burn mortality.

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