The pathogenesis of rift valley fever

Research output: Contribution to journalReview article

157 Scopus citations

Abstract

Rift Valley fever (RVF) is an emerging zoonotic disease distributed in sub-Saharan African countries and the Arabian Peninsula. The disease is caused by the Rift Valley fever virus (RVFV) of the family Bunyaviridae and the genus Phlebovirus. The virus is transmitted by mosquitoes, and virus replication in domestic ruminant results in high rates of mortality and abortion. RVFV infection in humans usually causes a self-limiting, acute and febrile illness; however, a small number of cases progress to neurological disorders, partial or complete blindness, hemorrhagic fever, or thrombosis. This review describes the pathology of RVF in human patients and several animal models, and summarizes the role of viral virulence factors and host factors that affect RVFV pathogenesis.

Original languageEnglish (US)
Pages (from-to)493-519
Number of pages27
JournalViruses
Volume3
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • Blindness
  • Encephalitis
  • Hemorrhagic fever
  • Pathogenesis
  • Rift valley fever virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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