The pathophysiology of inhalation injury

Perenlei Enkhbaatar, Linda E. Sousse, Robert A. Cox, David N. Herndon

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


Smoke inhalation injury is a detrimental complication of burn patients leading to high mortality. As a consequence of smoke inhalation, acute lung injury/acute respiratory distress syndrome aggravates morbidity in these patients, requiring extended ventilator support, longer ICU or hospital stay, and high cost. The acute pathophysiology of smoke inhalation injury has been relatively well studied, and a generally accepted standard of care is available for use in burn centers and hospitals worldwide. However long-term pathological changes in pulmonary function in burn survivors remain incompletely understood. Future studies should also focus on the pathophysiology of nonpulmonary multiorgan injuries/dysfunctions in both acute and chronic phases. This chapter summarizes the epidemiology and acute pathophysiology of both airway and pulmonary parenchymal damage following smoke inhalation. It also describes toxic smoke compounds with detailed treatment recommendations.

Original languageEnglish (US)
Title of host publicationTotal Burn Care
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
ISBN (Electronic)9780323497428
ISBN (Print)9780323476614
StatePublished - 2018


  • Burn
  • Diagnostics
  • Pathophysiology
  • Smoke inhalation
  • Toxic gas
  • Treatments

ASJC Scopus subject areas

  • General Medicine


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