The pathophysiology of inhalation injury - a review

D. L. Traber, H. A. Linares, David Herndon, T. Prien

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The inhalation of smoke results in a series of pathophysiological events involving the respiratory and circulatory systems. Upper airway injury is mainly the result of heat damage. The lesions of the tracheobronchial and parenchymal areas are more related to the chemicals present in the smoke. The initial damage of the tracheobronchial mucosa results in chemotaxis of leucocytes into the airway tissues, with release of inflammatory mediators and formation of exudative materials. Bronchial oedema, bronchoconstriction, and bronchial obstruction by cast materials develop. The pulmonary microvasculature shows a permeability type of lesion, which is the result of mediator release from entrapped polymorphonuclear cells. This parenchymal lesion may relate to the tracheo-bronchial damage and be the result of a reperfusion injury. The systemic changes which have been identified relate to an increase in microvascular permeability and a reduction of myocardial contractility secondary to the inhalation of the toxic products of smoke. These latter findings may help to explain the difficulty encountered in resuscitating some of the burn victims who have concomitant inhalation injury.

Original languageEnglish (US)
Pages (from-to)357-364
Number of pages8
JournalBurns
Volume14
Issue number5
DOIs
StatePublished - 1988

Fingerprint

Smoke
Inhalation
Wounds and Injuries
Leukocyte Chemotaxis
Bronchoconstriction
Poisons
Capillary Permeability
Cardiovascular System
Microvessels
Reperfusion Injury
Respiratory System
Permeability
Edema
Mucous Membrane
Hot Temperature
Lung

ASJC Scopus subject areas

  • Emergency Medicine
  • Surgery

Cite this

Traber, D. L., Linares, H. A., Herndon, D., & Prien, T. (1988). The pathophysiology of inhalation injury - a review. Burns, 14(5), 357-364. https://doi.org/10.1016/0305-4179(88)90003-4

The pathophysiology of inhalation injury - a review. / Traber, D. L.; Linares, H. A.; Herndon, David; Prien, T.

In: Burns, Vol. 14, No. 5, 1988, p. 357-364.

Research output: Contribution to journalArticle

Traber, DL, Linares, HA, Herndon, D & Prien, T 1988, 'The pathophysiology of inhalation injury - a review', Burns, vol. 14, no. 5, pp. 357-364. https://doi.org/10.1016/0305-4179(88)90003-4
Traber DL, Linares HA, Herndon D, Prien T. The pathophysiology of inhalation injury - a review. Burns. 1988;14(5):357-364. https://doi.org/10.1016/0305-4179(88)90003-4
Traber, D. L. ; Linares, H. A. ; Herndon, David ; Prien, T. / The pathophysiology of inhalation injury - a review. In: Burns. 1988 ; Vol. 14, No. 5. pp. 357-364.
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