The pathophysiology of smoke inhalation injury in a sheep model

David Herndon, D. L. Traber, G. D. Niehaus, H. A. Linares

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

This study describes an experimental model of smoke inhalation injury in sheep, in which the same pathophysiologic alterations occur as with clinical inhalation in man. Both the patients and the experimental sheep develop diffuse pulmonary mucosal sloughing, pulmonary edema, and a decrease in systemic oxygen tension. The results of this study indicate that the pulmonary edema is the result of an increase in microvascular permeability, characterized by increases in lung lymph flow (Qlym), lymph-to-plasma protein concentration ratio (L/P), and transvascular protein flux (Qlym x lung lymph protein concentration), while pulmonary vascular pressures remain constant. Neutrophil degranulation may contibute to the increased microvascular permeability.

Original languageEnglish (US)
Pages (from-to)1044-1051
Number of pages8
JournalJournal of Trauma
Volume24
Issue number12
StatePublished - 1984

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Smoke Inhalation Injury
Sheep
Lymph
Lung
Capillary Permeability
Pulmonary Edema
Inhalation
Blood Vessels
Blood Proteins
Proteins
Neutrophils
Theoretical Models
Oxygen
Pressure

ASJC Scopus subject areas

  • Surgery

Cite this

Herndon, D., Traber, D. L., Niehaus, G. D., & Linares, H. A. (1984). The pathophysiology of smoke inhalation injury in a sheep model. Journal of Trauma, 24(12), 1044-1051.

The pathophysiology of smoke inhalation injury in a sheep model. / Herndon, David; Traber, D. L.; Niehaus, G. D.; Linares, H. A.

In: Journal of Trauma, Vol. 24, No. 12, 1984, p. 1044-1051.

Research output: Contribution to journalArticle

Herndon, D, Traber, DL, Niehaus, GD & Linares, HA 1984, 'The pathophysiology of smoke inhalation injury in a sheep model', Journal of Trauma, vol. 24, no. 12, pp. 1044-1051.
Herndon D, Traber DL, Niehaus GD, Linares HA. The pathophysiology of smoke inhalation injury in a sheep model. Journal of Trauma. 1984;24(12):1044-1051.
Herndon, David ; Traber, D. L. ; Niehaus, G. D. ; Linares, H. A. / The pathophysiology of smoke inhalation injury in a sheep model. In: Journal of Trauma. 1984 ; Vol. 24, No. 12. pp. 1044-1051.
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