The persistent risk of chronicity in recurrent episodes of nonbipolar major depressive disorder: A prospective follow-up

M. B. Keller, P. W. Lavori, J. Rice, W. Coryell, R. M. Hirschfeld

Research output: Contribution to journalArticle

177 Scopus citations


The authors report on the course of illness in 101 patients who were in an episode (the 'index episode') of major depressive disorder when they entered a clinical research study, recovered from that episode, and then relapsed into a new episode (the 'first prospective episode') of the disorder. They found a 22% probability that these patients' first prospective episode would last at least 1 year, similar to the 21% rate of chronicity previously reported for the index episode. A long prior episode, older age, and low family income were found to predict chronicity in the first prospective episode.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalAmerican Journal of Psychiatry
Issue number1
StatePublished - Jan 1 1986


ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this