The pituitary-adrenocortical axis and the immune system

J. E. Blalock, E. M. Smith, W. J. Meyer

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Until recently, vitrually all interactions between the pituitary-adrenocortical axis and the immune system were largely attributed to the effects of glucocorticoids. Research in the last few years however has led to a drastically altered view of this interaction. This has principally resulted from the observations that cells of the immune system have receptors for, and are directly affected by, pituitary and hypothalamic peptides. Further, pituitary peptide hormones seem to be endogenous to the immune system and may act in an autocrine as well as endocrine fashion. As a result of these new developments, as well as a number of recent reviews on the effects of glucocorticoids om immune function this chapter will focus on the more recent findings.

Original languageEnglish (US)
Pages (from-to)1021-1038
Number of pages18
JournalClinics in Endocrinology and Metabolism
Issue number4
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Biochemistry
  • General Chemistry
  • Endocrinology


Dive into the research topics of 'The pituitary-adrenocortical axis and the immune system'. Together they form a unique fingerprint.

Cite this