The pituitary-adrenocortical axis and the immune system

J. E. Blalock, E. M. Smith, Walter Meyer

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Until recently, vitrually all interactions between the pituitary-adrenocortical axis and the immune system were largely attributed to the effects of glucocorticoids. Research in the last few years however has led to a drastically altered view of this interaction. This has principally resulted from the observations that cells of the immune system have receptors for, and are directly affected by, pituitary and hypothalamic peptides. Further, pituitary peptide hormones seem to be endogenous to the immune system and may act in an autocrine as well as endocrine fashion. As a result of these new developments, as well as a number of recent reviews on the effects of glucocorticoids om immune function this chapter will focus on the more recent findings.

Original languageEnglish (US)
Pages (from-to)1021-1038
Number of pages18
JournalClinics in Endocrinology and Metabolism
Volume14
Issue number4
StatePublished - 1985

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Immune system
Immune System
Glucocorticoids
Pituitary Hormones
Peptide Hormones
Peptides
Research

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Blalock, J. E., Smith, E. M., & Meyer, W. (1985). The pituitary-adrenocortical axis and the immune system. Clinics in Endocrinology and Metabolism, 14(4), 1021-1038.

The pituitary-adrenocortical axis and the immune system. / Blalock, J. E.; Smith, E. M.; Meyer, Walter.

In: Clinics in Endocrinology and Metabolism, Vol. 14, No. 4, 1985, p. 1021-1038.

Research output: Contribution to journalArticle

Blalock, JE, Smith, EM & Meyer, W 1985, 'The pituitary-adrenocortical axis and the immune system', Clinics in Endocrinology and Metabolism, vol. 14, no. 4, pp. 1021-1038.
Blalock, J. E. ; Smith, E. M. ; Meyer, Walter. / The pituitary-adrenocortical axis and the immune system. In: Clinics in Endocrinology and Metabolism. 1985 ; Vol. 14, No. 4. pp. 1021-1038.
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