The pituitary gland

Changes on MR images during the 1st year after delivery

Yukio Miki, Milliam L. Kataoka, Toshiya Shibata, Tabassum L. Haque, Mitsunori Kanagaki, Taro Shimono, Tomohisa Okada, Akira Hiraga, Sadahiko Nishizawa, Hiroyuki Ueda, Mahbubur Rahman, Junji Konishi

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To longitudinally and prospectively investigate changes in the volume and signal intensity on T1-weighted magnetic resonance (MR) images of the pituitary gland up to 1 year after delivery and evaluate whether termination of lactation has an effect on these parameters. MATERIALS AND METHODS: All participants provided informed consent for participation in the study, which was approved by the institutional review board. Thirteen volunteers (mean age, 28 years; age range, 26-32 years) underwent MR imaging 2 and 4 weeks after delivery and then at intervals of 0.5-2.0 months until 1 year after delivery. Eight participants terminated lactation during the study period. Sagittal and coronal T1-weighted images were obtained. Signal intensities of the anterior and posterior lobes of the pituitary were calculated relative to that of the pons. The volume of the pituitary was also calculated. Two-tailed paired Student t tests and separate simple linear regression analyses were used to test for statistically significant differences. RESULTS: The mean pituitary volume was 544 mm3 at 2 weeks, 523 mm3 at 4 months, 512 mm 3 at 8 months, and 511 mm3 at 12 months after delivery, with significant differences between 2 weeks and 4 months (P = .002) and between 4 and 8 months (P = .003) after delivery. The mean ratio of the signal intensity of the anterior lobe of the pituitary to the signal intensity of the pons was 1.11 at 2 weeks, 1.07 at 4 months, 1.03 at 8 months, and 1.00 at 12 months after delivery, with significant differences between 2 weeks and 4 months (P = .004) and between 4 and 8 months (P = .0001 ) after delivery. Termination of lactation had no statistically significant effect on pituitary volume or the ratio of the signal intensity of the anterior or posterior lobe of the pituitary to the signal intensity of the pons. CONCLUSION: The volume of the pituitary gland decreases up to 8 months after delivery, and the T1-weighted signal intensity of the anterior lobe of the pituitary decreases; termination of lactation has no statistically significant effect on these parameters.

Original languageEnglish (US)
Pages (from-to)999-1004
Number of pages6
JournalRadiology
Volume235
Issue number3
DOIs
StatePublished - Jun 2005
Externally publishedYes

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Pituitary Gland
Lactation
Anterior Pituitary Gland
Pons
Magnetic Resonance Spectroscopy
Posterior Pituitary Gland
Research Ethics Committees
Informed Consent
Volunteers
Linear Models
Regression Analysis
Magnetic Resonance Imaging
Students

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Miki, Y., Kataoka, M. L., Shibata, T., Haque, T. L., Kanagaki, M., Shimono, T., ... Konishi, J. (2005). The pituitary gland: Changes on MR images during the 1st year after delivery. Radiology, 235(3), 999-1004. https://doi.org/10.1148/radiol.2353040243

The pituitary gland : Changes on MR images during the 1st year after delivery. / Miki, Yukio; Kataoka, Milliam L.; Shibata, Toshiya; Haque, Tabassum L.; Kanagaki, Mitsunori; Shimono, Taro; Okada, Tomohisa; Hiraga, Akira; Nishizawa, Sadahiko; Ueda, Hiroyuki; Rahman, Mahbubur; Konishi, Junji.

In: Radiology, Vol. 235, No. 3, 06.2005, p. 999-1004.

Research output: Contribution to journalArticle

Miki, Y, Kataoka, ML, Shibata, T, Haque, TL, Kanagaki, M, Shimono, T, Okada, T, Hiraga, A, Nishizawa, S, Ueda, H, Rahman, M & Konishi, J 2005, 'The pituitary gland: Changes on MR images during the 1st year after delivery', Radiology, vol. 235, no. 3, pp. 999-1004. https://doi.org/10.1148/radiol.2353040243
Miki Y, Kataoka ML, Shibata T, Haque TL, Kanagaki M, Shimono T et al. The pituitary gland: Changes on MR images during the 1st year after delivery. Radiology. 2005 Jun;235(3):999-1004. https://doi.org/10.1148/radiol.2353040243
Miki, Yukio ; Kataoka, Milliam L. ; Shibata, Toshiya ; Haque, Tabassum L. ; Kanagaki, Mitsunori ; Shimono, Taro ; Okada, Tomohisa ; Hiraga, Akira ; Nishizawa, Sadahiko ; Ueda, Hiroyuki ; Rahman, Mahbubur ; Konishi, Junji. / The pituitary gland : Changes on MR images during the 1st year after delivery. In: Radiology. 2005 ; Vol. 235, No. 3. pp. 999-1004.
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AU - Miki, Yukio

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AU - Shibata, Toshiya

AU - Haque, Tabassum L.

AU - Kanagaki, Mitsunori

AU - Shimono, Taro

AU - Okada, Tomohisa

AU - Hiraga, Akira

AU - Nishizawa, Sadahiko

AU - Ueda, Hiroyuki

AU - Rahman, Mahbubur

AU - Konishi, Junji

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N2 - PURPOSE: To longitudinally and prospectively investigate changes in the volume and signal intensity on T1-weighted magnetic resonance (MR) images of the pituitary gland up to 1 year after delivery and evaluate whether termination of lactation has an effect on these parameters. MATERIALS AND METHODS: All participants provided informed consent for participation in the study, which was approved by the institutional review board. Thirteen volunteers (mean age, 28 years; age range, 26-32 years) underwent MR imaging 2 and 4 weeks after delivery and then at intervals of 0.5-2.0 months until 1 year after delivery. Eight participants terminated lactation during the study period. Sagittal and coronal T1-weighted images were obtained. Signal intensities of the anterior and posterior lobes of the pituitary were calculated relative to that of the pons. The volume of the pituitary was also calculated. Two-tailed paired Student t tests and separate simple linear regression analyses were used to test for statistically significant differences. RESULTS: The mean pituitary volume was 544 mm3 at 2 weeks, 523 mm3 at 4 months, 512 mm 3 at 8 months, and 511 mm3 at 12 months after delivery, with significant differences between 2 weeks and 4 months (P = .002) and between 4 and 8 months (P = .003) after delivery. The mean ratio of the signal intensity of the anterior lobe of the pituitary to the signal intensity of the pons was 1.11 at 2 weeks, 1.07 at 4 months, 1.03 at 8 months, and 1.00 at 12 months after delivery, with significant differences between 2 weeks and 4 months (P = .004) and between 4 and 8 months (P = .0001 ) after delivery. Termination of lactation had no statistically significant effect on pituitary volume or the ratio of the signal intensity of the anterior or posterior lobe of the pituitary to the signal intensity of the pons. CONCLUSION: The volume of the pituitary gland decreases up to 8 months after delivery, and the T1-weighted signal intensity of the anterior lobe of the pituitary decreases; termination of lactation has no statistically significant effect on these parameters.

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