The potential benefits and adverse effects of phytic acid supplement in streptozotocin-induced diabetic rats

F. O. Omoruyi, A. Budiaman, Y. Eng, F. E. Olumese, J. L. Hoesel, A. Ejilemele, Anthony Okorodudu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this study, the effect of phytic acid supplement on streptozotocin- induced diabetic rats was investigated. Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. Blood and organ samples were collected for assays. The average food intake was the highest and the body weight gain was the lowest in the group fed phytic acid supplement compared to the diabetic and normal control groups. There was a downward trend in intestinal amylase activity in the group fed phytic acid supplement compared to the other groups. The spike in random blood glucose was the lowest in the same group. We noted reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels in the group fed phytic acid supplement. Serum alkaline phosphatase and alanine amino transferase activities were significantly (P<0.05) increased by phytic acid supplementation. Systemic IL-1β level was significantly (P<0.05) elevated in the diabetic control and supplement treated groups. The liver lipogenic enzyme activities were not significantly altered among the groups. These results suggest that phytic acid supplementation may be beneficial in the management of diabetes mellitus. The observed adverse effect on the liver may be due to the combined effect of streptozotocin-induced diabetes and phytic acid supplementation.

Original languageEnglish (US)
Article number172494
JournalAdvances in Pharmacological Sciences
Volume2013
DOIs
StatePublished - 2013

Fingerprint

Phytic Acid
Streptozocin
Experimental Diabetes Mellitus
Liver
Amylases
Transferases
Serum
Interleukin-1
Alanine
HDL Cholesterol
Weight Gain
Alkaline Phosphatase
Blood Glucose
Rodentia
Diabetes Mellitus
Triglycerides
Eating
Cholesterol
Body Weight
Control Groups

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The potential benefits and adverse effects of phytic acid supplement in streptozotocin-induced diabetic rats. / Omoruyi, F. O.; Budiaman, A.; Eng, Y.; Olumese, F. E.; Hoesel, J. L.; Ejilemele, A.; Okorodudu, Anthony.

In: Advances in Pharmacological Sciences, Vol. 2013, 172494, 2013.

Research output: Contribution to journalArticle

Omoruyi, F. O. ; Budiaman, A. ; Eng, Y. ; Olumese, F. E. ; Hoesel, J. L. ; Ejilemele, A. ; Okorodudu, Anthony. / The potential benefits and adverse effects of phytic acid supplement in streptozotocin-induced diabetic rats. In: Advances in Pharmacological Sciences. 2013 ; Vol. 2013.
@article{aae0eb47bb104229bafbbb3602811eab,
title = "The potential benefits and adverse effects of phytic acid supplement in streptozotocin-induced diabetic rats",
abstract = "In this study, the effect of phytic acid supplement on streptozotocin- induced diabetic rats was investigated. Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. Blood and organ samples were collected for assays. The average food intake was the highest and the body weight gain was the lowest in the group fed phytic acid supplement compared to the diabetic and normal control groups. There was a downward trend in intestinal amylase activity in the group fed phytic acid supplement compared to the other groups. The spike in random blood glucose was the lowest in the same group. We noted reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels in the group fed phytic acid supplement. Serum alkaline phosphatase and alanine amino transferase activities were significantly (P<0.05) increased by phytic acid supplementation. Systemic IL-1β level was significantly (P<0.05) elevated in the diabetic control and supplement treated groups. The liver lipogenic enzyme activities were not significantly altered among the groups. These results suggest that phytic acid supplementation may be beneficial in the management of diabetes mellitus. The observed adverse effect on the liver may be due to the combined effect of streptozotocin-induced diabetes and phytic acid supplementation.",
author = "Omoruyi, {F. O.} and A. Budiaman and Y. Eng and Olumese, {F. E.} and Hoesel, {J. L.} and A. Ejilemele and Anthony Okorodudu",
year = "2013",
doi = "10.1155/2013/172494",
language = "English (US)",
volume = "2013",
journal = "Advances in Pharmacological Sciences",
issn = "1687-6334",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - The potential benefits and adverse effects of phytic acid supplement in streptozotocin-induced diabetic rats

AU - Omoruyi, F. O.

AU - Budiaman, A.

AU - Eng, Y.

AU - Olumese, F. E.

AU - Hoesel, J. L.

AU - Ejilemele, A.

AU - Okorodudu, Anthony

PY - 2013

Y1 - 2013

N2 - In this study, the effect of phytic acid supplement on streptozotocin- induced diabetic rats was investigated. Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. Blood and organ samples were collected for assays. The average food intake was the highest and the body weight gain was the lowest in the group fed phytic acid supplement compared to the diabetic and normal control groups. There was a downward trend in intestinal amylase activity in the group fed phytic acid supplement compared to the other groups. The spike in random blood glucose was the lowest in the same group. We noted reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels in the group fed phytic acid supplement. Serum alkaline phosphatase and alanine amino transferase activities were significantly (P<0.05) increased by phytic acid supplementation. Systemic IL-1β level was significantly (P<0.05) elevated in the diabetic control and supplement treated groups. The liver lipogenic enzyme activities were not significantly altered among the groups. These results suggest that phytic acid supplementation may be beneficial in the management of diabetes mellitus. The observed adverse effect on the liver may be due to the combined effect of streptozotocin-induced diabetes and phytic acid supplementation.

AB - In this study, the effect of phytic acid supplement on streptozotocin- induced diabetic rats was investigated. Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. Blood and organ samples were collected for assays. The average food intake was the highest and the body weight gain was the lowest in the group fed phytic acid supplement compared to the diabetic and normal control groups. There was a downward trend in intestinal amylase activity in the group fed phytic acid supplement compared to the other groups. The spike in random blood glucose was the lowest in the same group. We noted reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels in the group fed phytic acid supplement. Serum alkaline phosphatase and alanine amino transferase activities were significantly (P<0.05) increased by phytic acid supplementation. Systemic IL-1β level was significantly (P<0.05) elevated in the diabetic control and supplement treated groups. The liver lipogenic enzyme activities were not significantly altered among the groups. These results suggest that phytic acid supplementation may be beneficial in the management of diabetes mellitus. The observed adverse effect on the liver may be due to the combined effect of streptozotocin-induced diabetes and phytic acid supplementation.

UR - http://www.scopus.com/inward/record.url?scp=84896120918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896120918&partnerID=8YFLogxK

U2 - 10.1155/2013/172494

DO - 10.1155/2013/172494

M3 - Article

AN - SCOPUS:84896120918

VL - 2013

JO - Advances in Pharmacological Sciences

JF - Advances in Pharmacological Sciences

SN - 1687-6334

M1 - 172494

ER -