The protective effect of a DNA vaccine encoding the Toxoplasma gondii cyclophilin gene in BALB/c mice

P. Gong, Xiangsheng Huang, Q. Yu, Y. Li, J. Huang, J. Li, J. Yang, H. Li, G. Zhang, W. Ren, X. Zhang

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Toxoplasmosis is a world-wide zoonosis that causes significant public health and veterinary problems. The study of vaccines remains the most promising method for the future prevention and control of toxoplasmosis. Recombinant Toxoplasma gondii cyclophilin has been shown to have potent PPIase and IL-12-inducing activities, thus promoting the stabilization of T. gondii's life cycle and maintaining the survival of its host during evolution. In this study, the T. gondii cyclophilin gene was used to construct a DNA vaccine (pVAX1-TgCyP). The immune response and protective efficacy of the vaccine against T. gondii infection in BALB/c mice were evaluated. All BALB/c mice that were vaccinated with pVAX1-TgCyP developed a high response with TgCyP-specific antibodies, and significant splenocyte proliferation (P 

Original languageEnglish (US)
Pages (from-to)140-146
Number of pages7
JournalParasite Immunology
Volume35
Issue number3-4
DOIs
StatePublished - Mar 2013
Externally publishedYes

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Keywords

  • BALB/c mice
  • Cycliophilin
  • DNA vaccine
  • Th1 response
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Parasitology
  • Immunology

Cite this

Gong, P., Huang, X., Yu, Q., Li, Y., Huang, J., Li, J., Yang, J., Li, H., Zhang, G., Ren, W., & Zhang, X. (2013). The protective effect of a DNA vaccine encoding the Toxoplasma gondii cyclophilin gene in BALB/c mice. Parasite Immunology, 35(3-4), 140-146. https://doi.org/10.1111/pim.12024