The Proteomics of Cocaine in the Nucleus Accumbens

E. J. Crofton, Y. Zhang, Thomas Green

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cocaine addiction is a major health issue with no FDA-approved medication, so novel therapeutic target identification is necessary. Recent technological advances provide novel target identification using large-scale discovery-based quantification of the proteome in response to cocaine. This approach improves upon historically utilized methods as proteins are quantified regardless of whether the protein is regulated by the manipulation. Additionally, it avoids experimenter biases and assumptions and reduces labor and cost requirements. In this chapter we discuss proteome-wide effects of cocaine in the nucleus accumbens in rats that self-administered cocaine or saline, a paradigm with excellent reproducibility and strong validity as a model of drug-taking and -seeking behavior. Also discussed are the proteomic effects of environmental enrichment, which provides a unique opportunity for novel target identification as enrichment produces a robust protective behavioral addiction phenotype and therefore a strong potential for identification of novel targets with protective effects.

Original languageEnglish (US)
Title of host publicationThe Neuroscience of Cocaine
Subtitle of host publicationMechanisms and Treatment
PublisherElsevier Inc.
Pages173-182
Number of pages10
ISBN (Electronic)9780128037928
ISBN (Print)9780128037508
DOIs
StatePublished - May 16 2017

Keywords

  • Behavior
  • Bioinformatics
  • Cocaine
  • Drug addiction
  • Environmental enrichment
  • Nucleus accumbens
  • Proteomics
  • Ventral striatum

ASJC Scopus subject areas

  • Psychology(all)

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