The pulmonary lesion of smoke inhalation in an ovine model

D. L. Traber, David Herndon, M. D. Stein, J. T. Flynn, G. D. Niehaus

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Inhalation injury was induced in chronically instrumented sheep (n = 9) by insufflating them with smoke from burning cotton cloth. Sham animals (n = 9) were insufflated with air. There were no temporal changes in any measured parameter of the sham animals. Smoke induced a depression in PaO2. There was a threefold elevation in protein-rich pulmonary lymph which was sustained for over 48 hours. The lymph-to-plasma oncotic pressure ratio was increased. The cardiac index, left atrial pressure, and pulmonary arterial pressure remained unchanged in both groups. After smoke inhalation, the interstitial levels of neutrophils increased while interstitial antiprotease activity was depressed. The lung lymph concentration of 6-keto prostaglandin F(1a), the major metabolite of prostacyclin, was increased. These data suggest that the pulmonary injury following smoke inhalation is the result of an increase in lung microvascular permeability to protein with resultant pulmonary edema. The mechanisms responsible for these changes appear to be related to direct injury to the tracheobronchial tree by cytotoxic agents in the smoke; polymorphonuclear leukocytes; and, possibly, eicosanoids.

Original languageEnglish (US)
Pages (from-to)311-323
Number of pages13
JournalCirculatory Shock
Volume18
Issue number4
StatePublished - 1986

Fingerprint

Smoke
Inhalation
Sheep
Lymph
Lung
Neutrophils
Atrial Pressure
Eicosanoids
Cytotoxins
Wounds and Injuries
Capillary Permeability
Prostaglandins F
Lung Injury
Epoprostenol
Pulmonary Edema
Protease Inhibitors
Arterial Pressure
Proteins
Air
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Traber, D. L., Herndon, D., Stein, M. D., Flynn, J. T., & Niehaus, G. D. (1986). The pulmonary lesion of smoke inhalation in an ovine model. Circulatory Shock, 18(4), 311-323.

The pulmonary lesion of smoke inhalation in an ovine model. / Traber, D. L.; Herndon, David; Stein, M. D.; Flynn, J. T.; Niehaus, G. D.

In: Circulatory Shock, Vol. 18, No. 4, 1986, p. 311-323.

Research output: Contribution to journalArticle

Traber, DL, Herndon, D, Stein, MD, Flynn, JT & Niehaus, GD 1986, 'The pulmonary lesion of smoke inhalation in an ovine model', Circulatory Shock, vol. 18, no. 4, pp. 311-323.
Traber DL, Herndon D, Stein MD, Flynn JT, Niehaus GD. The pulmonary lesion of smoke inhalation in an ovine model. Circulatory Shock. 1986;18(4):311-323.
Traber, D. L. ; Herndon, David ; Stein, M. D. ; Flynn, J. T. ; Niehaus, G. D. / The pulmonary lesion of smoke inhalation in an ovine model. In: Circulatory Shock. 1986 ; Vol. 18, No. 4. pp. 311-323.
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