The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites

Sabrina Prudente, Manisha Chandalia, Eleonora Morini, Roberto Baratta, Bruno Dallapiccola, Nicola Abate, Lucia Fzrittitta, Vincenzo Trischitta

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study investigated the role of the ENPP1/PC-1 gene K121Q polymorphism in predicting BMI (kg/m2) in non-diabetic individuals. Three independent samples (n = 631, n = 304, and n = 505) of adult whites were analyzed. Selection criteria were fasting plasma glucose level <126 mg/dL, absence of severe obesity (BMI ≥40 kg/m2), and lack of treatment known to modulate BMI. In Sample 1, BMI values were different in individuals carrying the K121/K121 (KK), K121/Q121 (KQ), and Q121/Q121 (QQ) genotypes (25.5 ± 4.3, 25.3 ± 4.1, and 22.8 ± 2.5 kg/m2, respectively (adjusted p = 0.022); BMI values in Samples 2 and 3 also tended to be different, although the differences, after adjustment for age and sex, did not reach statistical significance. When data were pooled, BMI values were 25.8 ± 4.4, 25.6 ± 4.4, and 23.6 ± 3.3 kg/m2 in KK, KQ, and QQ individuals (adjusted p = 0.029). According to a recessive model, QQ individuals had lower BMI values than KK and KQ individuals combined (23.6 ± 3.3 kg/m2 vs. 25.7 ± 4.4 kg/m2; adjusted p = 0.008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalObesity
Volume15
Issue number1
StatePublished - Jan 2007
Externally publishedYes

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Genotype
Morbid Obesity
Patient Selection
Genes
Fasting
Obesity
Prospective Studies
Glucose
Therapeutics

Keywords

  • BMI
  • Genetic susceptibility

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Prudente, S., Chandalia, M., Morini, E., Baratta, R., Dallapiccola, B., Abate, N., ... Trischitta, V. (2007). The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites. Obesity, 15(1), 1-4.

The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites. / Prudente, Sabrina; Chandalia, Manisha; Morini, Eleonora; Baratta, Roberto; Dallapiccola, Bruno; Abate, Nicola; Fzrittitta, Lucia; Trischitta, Vincenzo.

In: Obesity, Vol. 15, No. 1, 01.2007, p. 1-4.

Research output: Contribution to journalArticle

Prudente, S, Chandalia, M, Morini, E, Baratta, R, Dallapiccola, B, Abate, N, Fzrittitta, L & Trischitta, V 2007, 'The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites', Obesity, vol. 15, no. 1, pp. 1-4.
Prudente S, Chandalia M, Morini E, Baratta R, Dallapiccola B, Abate N et al. The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites. Obesity. 2007 Jan;15(1):1-4.
Prudente, Sabrina ; Chandalia, Manisha ; Morini, Eleonora ; Baratta, Roberto ; Dallapiccola, Bruno ; Abate, Nicola ; Fzrittitta, Lucia ; Trischitta, Vincenzo. / The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites. In: Obesity. 2007 ; Vol. 15, No. 1. pp. 1-4.
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