The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites

Sabrina Prudente; Manisha Chandalia; Eleonora Morini; Roberto Baratta; Bruno Dallapiccola; Nicola Abate; Lucia Fzrittitta; Vincenzo Trischitta

doi:10.1038/oby.2007.636

The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites

Sabrina Prudente
, Manisha Chandalia
, Eleonora Morini
, Roberto Baratta
, Bruno Dallapiccola
, Nicola Abate
, Lucia Fzrittitta
, Vincenzo Trischitta

Internal Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

This study investigated the role of the ENPP1/PC-1 gene K121Q polymorphism in predicting BMI (kg/m²) in non-diabetic individuals. Three independent samples (n = 631, n = 304, and n = 505) of adult whites were analyzed. Selection criteria were fasting plasma glucose level <126 mg/dL, absence of severe obesity (BMI ≥40 kg/m²), and lack of treatment known to modulate BMI. In Sample 1, BMI values were different in individuals carrying the K121/K121 (KK), K121/Q121 (KQ), and Q121/Q121 (QQ) genotypes (25.5 ± 4.3, 25.3 ± 4.1, and 22.8 ± 2.5 kg/m², respectively (adjusted p = 0.022); BMI values in Samples 2 and 3 also tended to be different, although the differences, after adjustment for age and sex, did not reach statistical significance. When data were pooled, BMI values were 25.8 ± 4.4, 25.6 ± 4.4, and 23.6 ± 3.3 kg/m² in KK, KQ, and QQ individuals (adjusted p = 0.029). According to a recessive model, QQ individuals had lower BMI values than KK and KQ individuals combined (23.6 ± 3.3 kg/m² vs. 25.7 ± 4.4 kg/m²; adjusted p = 0.008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Obesity
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/oby.2007.636
State	Published - Jan 2007

Keywords

BMI
Genetic susceptibility

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

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10.1038/oby.2007.636

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title = "The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites",

abstract = "This study investigated the role of the ENPP1/PC-1 gene K121Q polymorphism in predicting BMI (kg/m2) in non-diabetic individuals. Three independent samples (n = 631, n = 304, and n = 505) of adult whites were analyzed. Selection criteria were fasting plasma glucose level <126 mg/dL, absence of severe obesity (BMI ≥40 kg/m2), and lack of treatment known to modulate BMI. In Sample 1, BMI values were different in individuals carrying the K121/K121 (KK), K121/Q121 (KQ), and Q121/Q121 (QQ) genotypes (25.5 ± 4.3, 25.3 ± 4.1, and 22.8 ± 2.5 kg/m2, respectively (adjusted p = 0.022); BMI values in Samples 2 and 3 also tended to be different, although the differences, after adjustment for age and sex, did not reach statistical significance. When data were pooled, BMI values were 25.8 ± 4.4, 25.6 ± 4.4, and 23.6 ± 3.3 kg/m2 in KK, KQ, and QQ individuals (adjusted p = 0.029). According to a recessive model, QQ individuals had lower BMI values than KK and KQ individuals combined (23.6 ± 3.3 kg/m2 vs. 25.7 ± 4.4 kg/m2; adjusted p = 0.008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity.",

keywords = "BMI, Genetic susceptibility",

author = "Sabrina Prudente and Manisha Chandalia and Eleonora Morini and Roberto Baratta and Bruno Dallapiccola and Nicola Abate and Lucia Fzrittitta and Vincenzo Trischitta",

year = "2007",

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doi = "10.1038/oby.2007.636",

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AU - Prudente, Sabrina

AU - Chandalia, Manisha

AU - Morini, Eleonora

AU - Baratta, Roberto

AU - Dallapiccola, Bruno

AU - Abate, Nicola

AU - Fzrittitta, Lucia

AU - Trischitta, Vincenzo

PY - 2007/1

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AB - This study investigated the role of the ENPP1/PC-1 gene K121Q polymorphism in predicting BMI (kg/m2) in non-diabetic individuals. Three independent samples (n = 631, n = 304, and n = 505) of adult whites were analyzed. Selection criteria were fasting plasma glucose level <126 mg/dL, absence of severe obesity (BMI ≥40 kg/m2), and lack of treatment known to modulate BMI. In Sample 1, BMI values were different in individuals carrying the K121/K121 (KK), K121/Q121 (KQ), and Q121/Q121 (QQ) genotypes (25.5 ± 4.3, 25.3 ± 4.1, and 22.8 ± 2.5 kg/m2, respectively (adjusted p = 0.022); BMI values in Samples 2 and 3 also tended to be different, although the differences, after adjustment for age and sex, did not reach statistical significance. When data were pooled, BMI values were 25.8 ± 4.4, 25.6 ± 4.4, and 23.6 ± 3.3 kg/m2 in KK, KQ, and QQ individuals (adjusted p = 0.029). According to a recessive model, QQ individuals had lower BMI values than KK and KQ individuals combined (23.6 ± 3.3 kg/m2 vs. 25.7 ± 4.4 kg/m2; adjusted p = 0.008). These data suggest that the QQ genotype of the ENPP1/PC-1 gene is associated with lower BMI. If similar results are confirmed in prospective studies, the K121Q polymorphism may help identify people at risk for obesity.

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JF - Obesity

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ER -

The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites

Abstract

Keywords

ASJC Scopus subject areas

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