The rate of training response to aerobic exercise affects brain function of rats

Orsolya Marton, Erika Koltai, Masaki Takeda, Tatsuya Mimura, Melitta Pajk, Dora Abraham, Lauren Gerard Koch, Steven L. Britton, Mitsuru Higuchi, Istvan Boldogh, Zsolt Radak

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

There is an increasing volume of data connecting capacity to respond to exercise training with quality of life and aging. In this study, we used a rat model in which animals were selectively bred for low and high gain in running distance to test t whether genetic segregation for trainability is associated with brain function and signaling processes in the hippocampus. Rats selected for low response (LRT) and high response training (HRT) were randomly divided into control or exercise group that trained five times a week for 30 min per day for three months at 70% VO2max. All four groups had similar running distance before training. With training, HRT rats showed significantly greater increases in VO2max and running distance than LRT rats (p <0.05). On the reverse Morris Maze test HRT-trained rats outperformed HRT control ones. Significant difference was noted between LRT and HRT groups in redox milieu as assessed by levels of reactive oxygen species (ROS), carbonylation of proteins, nNOS and S-nitroso-cysteine. Moreover the silent information regulator 1 (SIRT1), brain-derived neurotrophic factor (BDNF), ratio of phospho and total cAMP-response element binding protein (CREB), and apoptotic index, also showed significant differences between LRT and HRT groups. These findings suggest that aerobic training responses are not localized to skeletal muscle, but differently involve signaling processes in the brain of LRT and HRT rats.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalNeurochemistry International
Volume99
DOIs
StatePublished - Oct 1 2016

Fingerprint

Exercise
Brain
Running
Cyclic AMP Response Element-Binding Protein
Protein S
Brain-Derived Neurotrophic Factor
Oxidation-Reduction
Cysteine
Reactive Oxygen Species
Hippocampus
Skeletal Muscle
Quality of Life

Keywords

  • Brain derived neurotrophic factor
  • Brain function
  • Exercise
  • Redox signaling
  • Trainability

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Marton, O., Koltai, E., Takeda, M., Mimura, T., Pajk, M., Abraham, D., ... Radak, Z. (2016). The rate of training response to aerobic exercise affects brain function of rats. Neurochemistry International, 99, 16-23. https://doi.org/10.1016/j.neuint.2016.05.012

The rate of training response to aerobic exercise affects brain function of rats. / Marton, Orsolya; Koltai, Erika; Takeda, Masaki; Mimura, Tatsuya; Pajk, Melitta; Abraham, Dora; Koch, Lauren Gerard; Britton, Steven L.; Higuchi, Mitsuru; Boldogh, Istvan; Radak, Zsolt.

In: Neurochemistry International, Vol. 99, 01.10.2016, p. 16-23.

Research output: Contribution to journalArticle

Marton, O, Koltai, E, Takeda, M, Mimura, T, Pajk, M, Abraham, D, Koch, LG, Britton, SL, Higuchi, M, Boldogh, I & Radak, Z 2016, 'The rate of training response to aerobic exercise affects brain function of rats', Neurochemistry International, vol. 99, pp. 16-23. https://doi.org/10.1016/j.neuint.2016.05.012
Marton, Orsolya ; Koltai, Erika ; Takeda, Masaki ; Mimura, Tatsuya ; Pajk, Melitta ; Abraham, Dora ; Koch, Lauren Gerard ; Britton, Steven L. ; Higuchi, Mitsuru ; Boldogh, Istvan ; Radak, Zsolt. / The rate of training response to aerobic exercise affects brain function of rats. In: Neurochemistry International. 2016 ; Vol. 99. pp. 16-23.
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