The realities of biodefense vaccines against Rickettsia

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Rickettsia prowazekii, R. rickettsii, R. conorii, and R. typhi are serious biologic weapon threats because of high infectivity of low dose aerosols, stable small particle aerosol infectivity, virulence causing severe disease, difficulty in establishing a timely diagnosis, ineffectiveness of usualempiric treatments, potential for engineered complete antimicrobial resistance, lower level of immunity, availability of the agents in nature, and feasibility of propagation, stabilization, and dispersal. Infection induces long-term immunity, killed rickettsial vaccines stimulate incomplete protection, and a live attenuated mutant stimulates strong immunity but reverts to virulence. Prospects for rational development of a safe, effective live attenuated vaccine are excellent.

Original languageEnglish (US)
JournalVaccine
Volume27
Issue numberSUPPL. 4
DOIs
StatePublished - Nov 5 2009

Fingerprint

Rickettsia
Immunity
Vaccines
immunity
live vaccines
vaccines
aerosols
Aerosols
Rickettsial Vaccines
Virulence
Rickettsia prowazekii
virulence
pathogenicity
Attenuated Vaccines
Inactivated Vaccines
Weapons
antibiotic resistance
mutants
dosage
Infection

Keywords

  • Biodefense
  • Rickettsia
  • Vaccines
  • Weapons

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

The realities of biodefense vaccines against Rickettsia. / Walker, David.

In: Vaccine, Vol. 27, No. SUPPL. 4, 05.11.2009.

Research output: Contribution to journalArticle

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