The receptive part of the primary afferent axon is most vulnerable to systemic capsaicin in adult rats

K. Chung, C. M. Klein, R. E. Coggeshall

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The present study shows that systemic capsaicin in adult rats results in a significant loss of axons in the subepidermal nerve plexus of the posterior leg but no loss of axons in the sural nerves of these same animals. These data are interpreted as indicating that the receptive part of the peripheral sensory axon is destroyed but that the cell body and most of the peripheral axon remains intact. Thus we suggest that the receptive part of the peripheral sensory axon is the most vulnerable part of the primary afferent neuron to capsaicin in these animals. These findings may explain the observation that adult rats treated with systemic capsaicin are deficient in their responses to certain painful stimuli but usually do not show obvious signs of primary afferent neuron death. We also suggest that as the dose of capsaicin is increased the whole neuron dies. It remains to be determined if the peripheral damage reported here is related to the striking loss of primary afferent markers in the dorsal horn that is also seen after this treatment.

Original languageEnglish (US)
Pages (from-to)222-226
Number of pages5
JournalBrain Research
Volume511
Issue number2
DOIs
StatePublished - Mar 19 1990

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Capsaicin
Axons
Afferent Neurons
Sural Nerve
Leg
Neurons

Keywords

  • Capsaicin
  • Primary afferent axon
  • Subepidermal nerve plexus
  • Sural nerve

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

The receptive part of the primary afferent axon is most vulnerable to systemic capsaicin in adult rats. / Chung, K.; Klein, C. M.; Coggeshall, R. E.

In: Brain Research, Vol. 511, No. 2, 19.03.1990, p. 222-226.

Research output: Contribution to journalArticle

Chung, K. ; Klein, C. M. ; Coggeshall, R. E. / The receptive part of the primary afferent axon is most vulnerable to systemic capsaicin in adult rats. In: Brain Research. 1990 ; Vol. 511, No. 2. pp. 222-226.
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