The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic

Yamilka Díaz, Julio Cisneros, Hilda Guzmán, Paola Cordoba, Jean Paul Carrera, Brechla Moreno, Rubing Chen, Juan Castillo Mewa, Lourdes García, Lizbeth Cerezo, Amelia Travassos da Rosa, Nathan D. Gundacker, Blas Armién, Scott Weaver, Nikos Vasilakis, Sandra López-Vergès, Robert Tesh

Research output: Contribution to journalArticle

Abstract

The circulation of the South-east Asian/American (AS/AM) dengue 2 virus (DENV-2) genotype in the Americas has been associated with a high rate of severe disease. From 1993, the year DENV was reintroduced in Panama, until 2011 there were 29 dengue-associated deaths, 17 of which occurred in 2011, the most severe outbreak with a case fatality rate (CFR) of 44% (17 deaths out of 38 severe dengue cases). During this outbreak DENV-2 was reintroduced into the country, whereas over the prior five years DENV-1 and −3 were predominant. Herein, we describe the 2011 Panama outbreak and genetically characterize the Panamanian DENV-2 strains, which were associated with severe dengue disease in Panama. Our results suggest that the DENV-2 isolates from this outbreak belonged to the AS/AM genotype sub-clade 2BI and were genetically close to viruses described in the outbreaks in Nicaragua, Honduras, Guatemala and Mexico from 2006-2011. Sub-clade 2BI has previously been associated with severe disease in Nicaragua during outbreaks from 2005-2007.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalActa Tropica
Volume177
DOIs
StatePublished - Jan 1 2018

Fingerprint

Panama
Dengue virus
Disease Outbreaks
dengue
Nicaragua
Severe Dengue
Asian Americans
Genotype
Honduras
Guatemala
Dengue Virus
death
Dengue
Mexico
genotype
Viruses
Mortality
viruses

Keywords

  • case fatality rate
  • DENV-2
  • epidemiology
  • outbreak
  • phylogenetics

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Díaz, Y., Cisneros, J., Guzmán, H., Cordoba, P., Carrera, J. P., Moreno, B., ... Tesh, R. (2018). The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic. Acta Tropica, 177, 58-65. https://doi.org/10.1016/j.actatropica.2017.09.031

The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic. / Díaz, Yamilka; Cisneros, Julio; Guzmán, Hilda; Cordoba, Paola; Carrera, Jean Paul; Moreno, Brechla; Chen, Rubing; Mewa, Juan Castillo; García, Lourdes; Cerezo, Lizbeth; da Rosa, Amelia Travassos; Gundacker, Nathan D.; Armién, Blas; Weaver, Scott; Vasilakis, Nikos; López-Vergès, Sandra; Tesh, Robert.

In: Acta Tropica, Vol. 177, 01.01.2018, p. 58-65.

Research output: Contribution to journalArticle

Díaz, Y, Cisneros, J, Guzmán, H, Cordoba, P, Carrera, JP, Moreno, B, Chen, R, Mewa, JC, García, L, Cerezo, L, da Rosa, AT, Gundacker, ND, Armién, B, Weaver, S, Vasilakis, N, López-Vergès, S & Tesh, R 2018, 'The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic', Acta Tropica, vol. 177, pp. 58-65. https://doi.org/10.1016/j.actatropica.2017.09.031
Díaz, Yamilka ; Cisneros, Julio ; Guzmán, Hilda ; Cordoba, Paola ; Carrera, Jean Paul ; Moreno, Brechla ; Chen, Rubing ; Mewa, Juan Castillo ; García, Lourdes ; Cerezo, Lizbeth ; da Rosa, Amelia Travassos ; Gundacker, Nathan D. ; Armién, Blas ; Weaver, Scott ; Vasilakis, Nikos ; López-Vergès, Sandra ; Tesh, Robert. / The reintroduction of DENV-2 in 2011 in Panama and subsequent outbreak characteristic. In: Acta Tropica. 2018 ; Vol. 177. pp. 58-65.
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