The relationship between cognitive function and physical performance in older women

Results from the women's health initiative memory study

Hal H. Atkinson, Stephen R. Rapp, Jeff D. Williamson, James Lovato, John R. Absher, Margery Gass, Victor W. Henderson, Karen C. Johnson, John B. Kostis, Kaycee M. Sink, Charles Mouton, Judith K. Ockene, Marcia L. Stefanick, Dorothy S. Lane, Mark A. Espeland

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

BackgroundCognitive function and physical performance are associated, but the common sequence of cognitive and physical decline remains unclear.MethodsIn the Women's Health Initiative Memory Study (WHIMS) clinical trial, we examined associations at baseline and over a 6-year follow-up period between the Modified Mini-Mental State (3MS) Examination and three physical performance measures (PPMs): gait speed (meters/second), chair stands (number of stands in 15 seconds), and grip strength (kilograms). Using mixed models, we examined the baseline 3MS as predictor of change in PPM, change in the 3MS as predictor of change in PPM, and baseline PPM as predictors of 3MS change.ResultsAmong 1,793 women (mean age = 70.3 years, 89% white, and mean 3MS score = 95.1), PPM were weakly correlated with 3MS-gait speed: r =. 06, p =. 02; chair stands: r =. 09, p <. 001; and grip strength: r =. 10, p <. 001. Baseline 3MS score was associated with subsequent PPM decline after adjustment for demographics, comorbid conditions, medications, and lifestyle factors. For every SD (4.2 points) higher 3MS score, 0.04 SD (0.04 m/s) less gait speed and 0.05 SD (0.29 kg) less grip strength decline is expected over 6 years (p ≤. 01 both). Changes in 3MS and PPM were associated, particularly with chair stands and grip strength (p <. 003 both). Baseline PPMs were not associated with subsequent 3MS change.ConclusionsBaseline global cognitive function and change in global cognitive function were associated with physical performance change, but baseline physical performance was not associated with cognitive change in this cohort. These analyses support the hypothesis that cognitive decline on average precedes or co-occurs with physical performance decline.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume65 A
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

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Hand Strength
Women's Health
Cognition
Physical Examination
Life Style
Demography
Clinical Trials
Walking Speed
Cognitive Dysfunction

Keywords

  • Cognition
  • Cognitive function
  • Physical function
  • Physical performance

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

The relationship between cognitive function and physical performance in older women : Results from the women's health initiative memory study. / Atkinson, Hal H.; Rapp, Stephen R.; Williamson, Jeff D.; Lovato, James; Absher, John R.; Gass, Margery; Henderson, Victor W.; Johnson, Karen C.; Kostis, John B.; Sink, Kaycee M.; Mouton, Charles; Ockene, Judith K.; Stefanick, Marcia L.; Lane, Dorothy S.; Espeland, Mark A.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 65 A, No. 3, 03.2010, p. 300-306.

Research output: Contribution to journalArticle

Atkinson, HH, Rapp, SR, Williamson, JD, Lovato, J, Absher, JR, Gass, M, Henderson, VW, Johnson, KC, Kostis, JB, Sink, KM, Mouton, C, Ockene, JK, Stefanick, ML, Lane, DS & Espeland, MA 2010, 'The relationship between cognitive function and physical performance in older women: Results from the women's health initiative memory study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 65 A, no. 3, pp. 300-306. https://doi.org/10.1093/gerona/glp149
Atkinson, Hal H. ; Rapp, Stephen R. ; Williamson, Jeff D. ; Lovato, James ; Absher, John R. ; Gass, Margery ; Henderson, Victor W. ; Johnson, Karen C. ; Kostis, John B. ; Sink, Kaycee M. ; Mouton, Charles ; Ockene, Judith K. ; Stefanick, Marcia L. ; Lane, Dorothy S. ; Espeland, Mark A. / The relationship between cognitive function and physical performance in older women : Results from the women's health initiative memory study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2010 ; Vol. 65 A, No. 3. pp. 300-306.
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abstract = "BackgroundCognitive function and physical performance are associated, but the common sequence of cognitive and physical decline remains unclear.MethodsIn the Women's Health Initiative Memory Study (WHIMS) clinical trial, we examined associations at baseline and over a 6-year follow-up period between the Modified Mini-Mental State (3MS) Examination and three physical performance measures (PPMs): gait speed (meters/second), chair stands (number of stands in 15 seconds), and grip strength (kilograms). Using mixed models, we examined the baseline 3MS as predictor of change in PPM, change in the 3MS as predictor of change in PPM, and baseline PPM as predictors of 3MS change.ResultsAmong 1,793 women (mean age = 70.3 years, 89{\%} white, and mean 3MS score = 95.1), PPM were weakly correlated with 3MS-gait speed: r =. 06, p =. 02; chair stands: r =. 09, p <. 001; and grip strength: r =. 10, p <. 001. Baseline 3MS score was associated with subsequent PPM decline after adjustment for demographics, comorbid conditions, medications, and lifestyle factors. For every SD (4.2 points) higher 3MS score, 0.04 SD (0.04 m/s) less gait speed and 0.05 SD (0.29 kg) less grip strength decline is expected over 6 years (p ≤. 01 both). Changes in 3MS and PPM were associated, particularly with chair stands and grip strength (p <. 003 both). Baseline PPMs were not associated with subsequent 3MS change.ConclusionsBaseline global cognitive function and change in global cognitive function were associated with physical performance change, but baseline physical performance was not associated with cognitive change in this cohort. These analyses support the hypothesis that cognitive decline on average precedes or co-occurs with physical performance decline.",
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AU - Lovato, James

AU - Absher, John R.

AU - Gass, Margery

AU - Henderson, Victor W.

AU - Johnson, Karen C.

AU - Kostis, John B.

AU - Sink, Kaycee M.

AU - Mouton, Charles

AU - Ockene, Judith K.

AU - Stefanick, Marcia L.

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N2 - BackgroundCognitive function and physical performance are associated, but the common sequence of cognitive and physical decline remains unclear.MethodsIn the Women's Health Initiative Memory Study (WHIMS) clinical trial, we examined associations at baseline and over a 6-year follow-up period between the Modified Mini-Mental State (3MS) Examination and three physical performance measures (PPMs): gait speed (meters/second), chair stands (number of stands in 15 seconds), and grip strength (kilograms). Using mixed models, we examined the baseline 3MS as predictor of change in PPM, change in the 3MS as predictor of change in PPM, and baseline PPM as predictors of 3MS change.ResultsAmong 1,793 women (mean age = 70.3 years, 89% white, and mean 3MS score = 95.1), PPM were weakly correlated with 3MS-gait speed: r =. 06, p =. 02; chair stands: r =. 09, p <. 001; and grip strength: r =. 10, p <. 001. Baseline 3MS score was associated with subsequent PPM decline after adjustment for demographics, comorbid conditions, medications, and lifestyle factors. For every SD (4.2 points) higher 3MS score, 0.04 SD (0.04 m/s) less gait speed and 0.05 SD (0.29 kg) less grip strength decline is expected over 6 years (p ≤. 01 both). Changes in 3MS and PPM were associated, particularly with chair stands and grip strength (p <. 003 both). Baseline PPMs were not associated with subsequent 3MS change.ConclusionsBaseline global cognitive function and change in global cognitive function were associated with physical performance change, but baseline physical performance was not associated with cognitive change in this cohort. These analyses support the hypothesis that cognitive decline on average precedes or co-occurs with physical performance decline.

AB - BackgroundCognitive function and physical performance are associated, but the common sequence of cognitive and physical decline remains unclear.MethodsIn the Women's Health Initiative Memory Study (WHIMS) clinical trial, we examined associations at baseline and over a 6-year follow-up period between the Modified Mini-Mental State (3MS) Examination and three physical performance measures (PPMs): gait speed (meters/second), chair stands (number of stands in 15 seconds), and grip strength (kilograms). Using mixed models, we examined the baseline 3MS as predictor of change in PPM, change in the 3MS as predictor of change in PPM, and baseline PPM as predictors of 3MS change.ResultsAmong 1,793 women (mean age = 70.3 years, 89% white, and mean 3MS score = 95.1), PPM were weakly correlated with 3MS-gait speed: r =. 06, p =. 02; chair stands: r =. 09, p <. 001; and grip strength: r =. 10, p <. 001. Baseline 3MS score was associated with subsequent PPM decline after adjustment for demographics, comorbid conditions, medications, and lifestyle factors. For every SD (4.2 points) higher 3MS score, 0.04 SD (0.04 m/s) less gait speed and 0.05 SD (0.29 kg) less grip strength decline is expected over 6 years (p ≤. 01 both). Changes in 3MS and PPM were associated, particularly with chair stands and grip strength (p <. 003 both). Baseline PPMs were not associated with subsequent 3MS change.ConclusionsBaseline global cognitive function and change in global cognitive function were associated with physical performance change, but baseline physical performance was not associated with cognitive change in this cohort. These analyses support the hypothesis that cognitive decline on average precedes or co-occurs with physical performance decline.

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