@article{276bf30849a746f4bb1569970a986d72,
title = "The relationship of maternal glycemia to childhood obesity and metabolic dysfunction‡ ",
abstract = "Objective: To determine the association of maternal glycemia with childhood obesity and metabolic dysfunction. Study design: Secondary analysis of follow-up data 5–10 years after a mild gestational diabetes mellitus (GDM) treatment trial. The relationship between maternal oral glucose tolerance testing (OGTT) at 24–31-week gestation and body mass index (BMI), fasting glucose, insulin, and anthropometric measurements (sum of skinfolds, subscapular/triceps ratio, and waist circumference) in the offspring of untreated mild GDM and non-GDM (abnormal 50-g screen/normal OGTT) women was assessed. Multivariable regression modeling controlling for maternal and neonatal characteristics was employed. Results: A cohort of 236 untreated mild GDM and 480 non-GDM offspring were analyzed. In the combined cohort, significant correlations existed between fasting, 1, 2, and 3 h maternal glucose and subscapular/triceps ratio (all p <.04) and in all OGTT values other than the 2-hour value for homeostatic model assessment-estimated insulin resistance (HOMA-IR) (all p <.04) and sum of skinfold measurements (all p <.03). No correlation was found between OGTT values and childhood BMI Z-score. Multivariable regression modeling showed that OGTT values were associated with only sum of skinfolds and subscapular/triceps ratio and not with childhood BMI Z-score. Hispanic ethnicity and prepregnancy maternal BMI were most consistently related to childhood BMI Z-score and HOMA-IR, and Hispanic ethnicity with fasting glucose. Conclusions: Among women with untreated mild GDM and those without GDM, maternal glycemia is associated with childhood anthropometric measures of obesity but not childhood BMI, fasting glucose, or insulin resistance. Hispanic ethnicity, maternal BMI, and gestational weight gain were consistently related to childhood BMI.",
keywords = "Childhood obesity, fetal programing, maternal diabetes",
author = "{on behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network} and Landon, {Mark B.} and Lisa Mele and Varner, {Michael W.} and Casey, {Brian M.} and Reddy, {Uma M.} and Wapner, {Ronald J.} and Rouse, {Dwight J.} and Tita, {Alan T.N.} and Thorp, {John M.} and Chien, {Edward K.} and George Saade and William Grobman and Blackwell, {Sean C.} and VanDorsten, {J. Peter}",
note = "Funding Information: The project described was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [HD27915, HD36801, HD34208, HD34116, HD40485, HD40500, HD27869, HD40560, HD40544, HD53097, HD40512, HD40545] and the National Institutes of Health{\textquoteright}s National Center for Advancing Translational Sciences (NCATS) [UL1TR001070, UL1TR000439]. The authors thank Celeste Durnwald, M.D (University of Pennsylvania, School of Medicine, Philadelphia, PA, United States of America) for contributions to the design of this study; Patrick Catalano, MD (Case Western Reserve University–MetroHealth Medical Center, Cleveland, OH) for contributions to the design of this study and review of the manuscript; and subcommittee members Francee Johnson, RN, BSN (the Ohio State University College of Medicine, Columbus, OH, USA) and Lisa Moseley, R.N. (University of Texas Southwestern Medical Center, Dallas, TX, USA) for protocol development and coordination between clinical research centers, Lindsey Doherty, M.S. (George Washington University Biostatistics Center, Washington, DC, USA) for protocol/data management, and Madeline M. Rice, Ph.D. (George Washington University Biostatistics Center, Washington, DC, USA), Elizabeth Thom, Ph.D. (George Washington University Biostatistics Center, Washington, DC, USA) and Catherine Y. Spong, M.D. (Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA) for protocol development and oversight. Funding Information: The project described was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [HD27915, HD36801, HD34208, HD34116, HD40485, HD40500, HD27869, HD40560, HD40544, HD53097, HD40512, HD40545] and the National Institutes of Health{\textquoteright}s National Center for Advancing Translational Sciences (NCATS) [UL1TR001070, UL1TR000439]. Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Informa UK Limited, trading as Taylor & Francis Group.",
year = "2020",
month = jan,
day = "2",
doi = "10.1080/14767058.2018.1484094",
language = "English (US)",
volume = "33",
pages = "33--41",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "1",
}