The reticuloendothelium as the target in a virus infection

Pichinde virus pathogenesis in two strains of hamsters

F. A. Murphy, M. J. Buchmeier, W. E. Rawls

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The course of Pichinde virus infection in two strains of hamsters, LVG and MHA, was studied by sequential frozen-section immunofluorescence and light and electron microscopy. The major destructive effects of the infection were in the spleen and liver. In the spleen, primary target cells were macrophages in the marginal zone of the white pulp with subsequent spread into elements of the red pulp. In the liver, there was Kupffer cell and hepatocellular infection. The extent of involvement correlated with the outcome of infection; more extensive and progressive necrosis occurred in the fatally infected MHA than in the LVG strain in which infection was self-limiting. In neither strain of animal was there demonstrable infection of lymphoid cells. Similarly, lesion sites did not have mononuclear inflammatory infiltrations which are characteristic of most viral infections. These findings suggested that, in contrast to the situation in other rodent arenavirus infections, the lesions in these hamsters were probably not consequences of immunopathologic host response but rather were a result of direct viral effects in concert with a genetically determined host susceptibility.

Original languageEnglish (US)
Pages (from-to)502-515
Number of pages14
JournalLaboratory Investigation
Volume37
Issue number5
StatePublished - 1977

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Pichinde virus
Virus Diseases
Cricetinae
Infection
Arenaviridae Infections
Spleen
Kupffer Cells
Liver
Frozen Sections
Fluorescence Microscopy
Rodentia
Electron Microscopy
Necrosis
Macrophages
Lymphocytes
Light

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The reticuloendothelium as the target in a virus infection : Pichinde virus pathogenesis in two strains of hamsters. / Murphy, F. A.; Buchmeier, M. J.; Rawls, W. E.

In: Laboratory Investigation, Vol. 37, No. 5, 1977, p. 502-515.

Research output: Contribution to journalArticle

Murphy, F. A. ; Buchmeier, M. J. ; Rawls, W. E. / The reticuloendothelium as the target in a virus infection : Pichinde virus pathogenesis in two strains of hamsters. In: Laboratory Investigation. 1977 ; Vol. 37, No. 5. pp. 502-515.
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