TY - CHAP
T1 - The role and function of specialized blood-neuronal barriers
T2 - Blood-CSF, blood-retinal, blood-spinal cord, blood-labyrinth, blood-nerve barriers, and blood-brain barrier (BBB)
AU - Petronilho, Fabrícia
AU - Giustina, Amanda Della
AU - Danielski, Lucinéia Gainski
N1 - Publisher Copyright:
© 2025 Elsevier Inc. All rights reserved.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - The central nervous system (CNS) is protected by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). These barriers tightly control the passage of immune cells, molecules, and pathogens into the CNS. In addition to the well-known BBB and BCSFB, other lesser-known barriers between the brain and the retina, the nasal cavity, the labyrinth, or the blood-nerve-brain, and the glymphatic system, also contribute to the immune functions of the CNS and require further investigation. The immunological defense mechanisms at these barriers involve complex interactions between resident immune cells, endothelial cells, pericytes, and neural tissue. An inflammatory reaction can lead to molecular changes in these cells and result in the recruitment and activation of immune cells at the barriers. Understanding the immunological defense mechanisms of specialized blood neuronal barriers against infection is critical for developing therapeutic strategies to combat CNS infections. This chapter summarizes the immune responses at the brain barriers during infection involving various pathogens.
AB - The central nervous system (CNS) is protected by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). These barriers tightly control the passage of immune cells, molecules, and pathogens into the CNS. In addition to the well-known BBB and BCSFB, other lesser-known barriers between the brain and the retina, the nasal cavity, the labyrinth, or the blood-nerve-brain, and the glymphatic system, also contribute to the immune functions of the CNS and require further investigation. The immunological defense mechanisms at these barriers involve complex interactions between resident immune cells, endothelial cells, pericytes, and neural tissue. An inflammatory reaction can lead to molecular changes in these cells and result in the recruitment and activation of immune cells at the barriers. Understanding the immunological defense mechanisms of specialized blood neuronal barriers against infection is critical for developing therapeutic strategies to combat CNS infections. This chapter summarizes the immune responses at the brain barriers during infection involving various pathogens.
KW - Blood-neuronal barriers
KW - Immune response
KW - Infectious disease
KW - Nervous system
KW - Neuroinflammation
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U2 - 10.1016/B978-0-443-19130-5.00004-6
DO - 10.1016/B978-0-443-19130-5.00004-6
M3 - Chapter
AN - SCOPUS:85213168795
SN - 9780443191312
SP - 49
EP - 69
BT - Neurobiology of Infectious Diseases
PB - Elsevier
ER -