The role and function of specialized blood-neuronal barriers: Blood-CSF, blood-retinal, blood-spinal cord, blood-labyrinth, blood-nerve barriers, and blood-brain barrier (BBB)

Fabrícia Petronilho, Amanda Della Giustina, Lucinéia Gainski Danielski

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The central nervous system (CNS) is protected by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). These barriers tightly control the passage of immune cells, molecules, and pathogens into the CNS. In addition to the well-known BBB and BCSFB, other lesser-known barriers between the brain and the retina, the nasal cavity, the labyrinth, or the blood-nerve-brain, and the glymphatic system, also contribute to the immune functions of the CNS and require further investigation. The immunological defense mechanisms at these barriers involve complex interactions between resident immune cells, endothelial cells, pericytes, and neural tissue. An inflammatory reaction can lead to molecular changes in these cells and result in the recruitment and activation of immune cells at the barriers. Understanding the immunological defense mechanisms of specialized blood neuronal barriers against infection is critical for developing therapeutic strategies to combat CNS infections. This chapter summarizes the immune responses at the brain barriers during infection involving various pathogens.

Original languageEnglish (US)
Title of host publicationNeurobiology of Infectious Diseases
PublisherElsevier
Pages49-69
Number of pages21
ISBN (Electronic)9780443191305
ISBN (Print)9780443191312
DOIs
StatePublished - Jan 1 2024
Externally publishedYes

Keywords

  • Blood-neuronal barriers
  • Immune response
  • Infectious disease
  • Nervous system
  • Neuroinflammation

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'The role and function of specialized blood-neuronal barriers: Blood-CSF, blood-retinal, blood-spinal cord, blood-labyrinth, blood-nerve barriers, and blood-brain barrier (BBB)'. Together they form a unique fingerprint.

Cite this