The role of 15-lipoxygenase-l expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas

M. E. Sak, I. Alanbay, Ana Rodriguez, T. Gokaslan, M. Borahay, I. Shureiqi, Gokhan Kilic

Research output: Contribution to journalArticle

4 Scopus citations


Purpose of Investigation: To investigate the presence of 15-lipoxygenase-1 (15-LOX-1) expression and its potential role in the pathogenesis of endometrial hyperplasia and endometrial adenocarcinomas. Materials and Methods: The authors investigated the presence of 15-LOX-l expression in samples from patients diagnosed with normal endometrium (n = 12), endometrial hyperplasia (n = 12), and endometrial cancer (n = 12). The immunohistochemical stainings were scored by three independent pathologists. A Western blot of 15-LOX-l determined the presence of protein expression in normal endometrium. A Kolmogorov-Smimov test was used to evaluate the data's distribution pattern. For pairwise comparisons of the combined scores between groups, the Mann-Whitney U test was used. Results: Based on the combined scores for 15-LOX-l expression, strong immunochemistry staining was observed in samples diagnosed with normal endometrium. There was a significant difference in 15-LOX-l expression between normal endometrium and endometrial adenocarcinoma (p = 0.03). Comparing tissues from normal endometrium and endometrial hyperplasia, there was a decline in the expression from normal endometrium to endometrial hyperplasia. However, the difference was not statistically significant. Conclusion: The present results show that a decrease of 15-LOX-l expression in the endometrial tumorigenesis process, starting from normal endometrium to hyperplasia and endometrial cancer, might be a trigger. Further studies are required to determine its potential use as a marker in a larger randomized multicenter study.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalEuropean Journal of Gynaecological Oncology
Issue number1
StatePublished - 2016



  • 15-LOX-1, endometrial hyperplasia
  • Endometrial adenocarcinomas

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this