TY - JOUR
T1 - The role of acid stress in Salmonella pathogenesis
AU - Kenney, Linda J.
N1 - Funding Information:
I am grateful to my present and past laboratory members for their experimental and intellectual contributions to this work. I also thank Melanie Lee of the MBI SciComm team for illustrations and MP Sheetz for critical comments on the manuscript. Supported by VAIOBX-000372 and NIHAI123640 and a Research Centre of Excellence in Mechanobiology from the Ministry of Education, Singapore.
Funding Information:
I am grateful to my present and past laboratory members for their experimental and intellectual contributions to this work. I also thank Melanie Lee of the MBI SciComm team for illustrations and MP Sheetz for critical comments on the manuscript. Supported by VA IOBX-000372 and NIH AI123640 and a Research Centre of Excellence in Mechanobiology from the Ministry of Education, Singapore .
Publisher Copyright:
© 2018
PY - 2019/2
Y1 - 2019/2
N2 - After uptake by epithelial cells or engulfment by macrophages, Salmonella resides in an acidic vacuole. Salmonella senses this acidic compartment through the action of the EnvZ/OmpR two-component regulatory system. OmpR, in turn, represses the cadC/BA system, preventing neutralization of the bacterial cytoplasm. New, single cell techniques now enable us to observe that in response to acid stress, the pH is low in bacterial cells and acidification is critical for infection. Instead of recovering from acid stress, Salmonella uses acid pH as a signal to drive pathogenesis. The relevant molecular mechanisms employed by Salmonella to couple acid stress with the expression of virulence genes that promote intracellular survival are explored.
AB - After uptake by epithelial cells or engulfment by macrophages, Salmonella resides in an acidic vacuole. Salmonella senses this acidic compartment through the action of the EnvZ/OmpR two-component regulatory system. OmpR, in turn, represses the cadC/BA system, preventing neutralization of the bacterial cytoplasm. New, single cell techniques now enable us to observe that in response to acid stress, the pH is low in bacterial cells and acidification is critical for infection. Instead of recovering from acid stress, Salmonella uses acid pH as a signal to drive pathogenesis. The relevant molecular mechanisms employed by Salmonella to couple acid stress with the expression of virulence genes that promote intracellular survival are explored.
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U2 - 10.1016/j.mib.2018.11.006
DO - 10.1016/j.mib.2018.11.006
M3 - Review article
C2 - 30529007
AN - SCOPUS:85057790311
SN - 1369-5274
VL - 47
SP - 45
EP - 51
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -