The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

Urmi Sengupta, Ashley N. Nilson, Rakez Kayed

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The incidence of Alzheimer's disease (AD) is growing every day and finding an effective treatment is becoming more vital. Amyloid-β (Aβ) has been the focus of research for several decades. The recent shift in the Aβ cascade hypothesis from all Aβ to small soluble oligomeric intermediates is directing the search for therapeutics towards the toxic mediators of the disease. Targeting the most toxic oligomers may prove to be an effective treatment by preventing their spread. Specific targeting of oligomers has been shown to protect cognition in rodent models. Additionally, the heterogeneity of research on Aβ oligomers may seem contradictory until size and conformation are taken into account. In this review, we will discuss Aβ oligomers and their toxicity in relation to size and conformation as well as their influence on inflammation and the potential of Aβ oligomer immunotherapy.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalEBioMedicine
Volume6
DOIs
StatePublished - Apr 1 2016

Fingerprint

Oligomers
Amyloid
Immunotherapy
Toxicity
Poisons
Conformations
Research
Cognition
Rodentia
Alzheimer Disease
Therapeutics
Inflammation
Incidence

Keywords

  • Amyloid-β
  • Immunotherapy
  • Inflammation
  • Oligomers
  • Size
  • Toxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy. / Sengupta, Urmi; Nilson, Ashley N.; Kayed, Rakez.

In: EBioMedicine, Vol. 6, 01.04.2016, p. 42-49.

Research output: Contribution to journalArticle

Sengupta, Urmi ; Nilson, Ashley N. ; Kayed, Rakez. / The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy. In: EBioMedicine. 2016 ; Vol. 6. pp. 42-49.
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