The role of androgens and estrogens on healthy aging and longevity

Astrid M. Horstman, Edgar Dillon, Randall Urban, Melinda Sheffield-Moore

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Aging is associated with a loss of sex hormone in both men (andropause) and women (menopause). In men, reductions in testosterone can trigger declines in muscle mass, bone mass, and in physical function. In women, the impact of the loss of sex hormones, such as estradiol, on bone is well elucidated, but evidence is limited on whether the loss of estradiol negatively affects muscle mass and physical function. However, deficiencies in multiple anabolic hormones have been shown to predict health status and longevity in older persons. Thus, consideration should be given as to whether targeted hormone replacement therapies may prove effective at treating clinical conditions, such as age-related sarcopenia, cancer cachexia, and/or acute or chronic illnesses. If initiated carefully in the appropriate clinical population, hormone replacement therapies in men and women may prevent and reverse muscle and bone loss and functional declines and perhaps promote healthy aging and longevity.

Original languageEnglish (US)
Pages (from-to)1140-1152
Number of pages13
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67
Issue number11
DOIs
StatePublished - Nov 2012

Fingerprint

Androgens
Estrogens
Hormone Replacement Therapy
Gonadal Steroid Hormones
Bone and Bones
Muscles
Estradiol
Andropause
Sarcopenia
Cachexia
Population Dynamics
Menopause
Health Status
Testosterone
Chronic Disease
Hormones
Neoplasms

Keywords

  • Aging
  • Longevity
  • Muscle
  • Sarcopenia
  • Testosterone

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

The role of androgens and estrogens on healthy aging and longevity. / Horstman, Astrid M.; Dillon, Edgar; Urban, Randall; Sheffield-Moore, Melinda.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 67, No. 11, 11.2012, p. 1140-1152.

Research output: Contribution to journalArticle

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