The role of androgens and estrogens on healthy aging and longevity

Astrid M. Horstman, E. Lichar Dillon, Randall J. Urban, Melinda Sheffield-Moore

Research output: Contribution to journalReview article

110 Scopus citations

Abstract

Aging is associated with a loss of sex hormone in both men (andropause) and women (menopause). In men, reductions in testosterone can trigger declines in muscle mass, bone mass, and in physical function. In women, the impact of the loss of sex hormones, such as estradiol, on bone is well elucidated, but evidence is limited on whether the loss of estradiol negatively affects muscle mass and physical function. However, deficiencies in multiple anabolic hormones have been shown to predict health status and longevity in older persons. Thus, consideration should be given as to whether targeted hormone replacement therapies may prove effective at treating clinical conditions, such as age-related sarcopenia, cancer cachexia, and/or acute or chronic illnesses. If initiated carefully in the appropriate clinical population, hormone replacement therapies in men and women may prevent and reverse muscle and bone loss and functional declines and perhaps promote healthy aging and longevity.

Original languageEnglish (US)
Pages (from-to)1140-1152
Number of pages13
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume67
Issue number11
DOIs
StatePublished - Nov 1 2012

Keywords

  • Aging
  • Longevity
  • Muscle
  • Sarcopenia
  • Testosterone

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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