Abstract
Purpose: The present study was designed to examine apoptotic cell death via the caspase-dependent pathway in human fetal membranes. Methods: Amniotic membrane samples were collected from three groups of women: group 1, women with preterm premature rupture of fetal membranes (PPROM) after cesarean delivery (n = 10), group 2, women with preterm labor (PTL) with intact membranes after cesarean delivery (n = 9) and group 3, women with term labor and vaginal delivery after an uncomplicated pregnancy (controls) (n = 11). Results: Active caspase-3 immunopositivity (ACPI) of the PPROM group was significantly higher than that of the control group (p < 0.05). ACPI was higher in the PTL with intact membranes group as compared to the control group; however, it did not reach statistical significance (p > 0.05). Conclusion: Active caspase-3 positivity is increased in the fetal membranes of those women with PPROM.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 501-505 |
| Number of pages | 5 |
| Journal | Archives of Gynecology and Obstetrics |
| Volume | 288 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2013 |
| Externally published | Yes |
Keywords
- Apoptosis
- Caspase-3
- Preterm labor
- Preterm premature rupture of membranes
ASJC Scopus subject areas
- Obstetrics and Gynecology