The role of bacterial vaginosis and trichomonas in HIV transmission across the female genital tract

Paria Mirmonsef, Laurie Krass, Alan Landay, Gregory T. Spear

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Bacterial vaginosis (BV) and Trichomonas vaginalis (TV) infections are both very common and are associated with increased risk of sexual transmission of HIV. There are several mechanisms by which BV and TV could affect susceptibility including inducing pro-inflammatory cytokines and disrupting mucosal barrier function. This review highlights recent advances in our understanding of how these genital conditions lead to an increased risk of HIV infection in women.

Original languageEnglish (US)
Pages (from-to)202-210
Number of pages9
JournalCurrent HIV Research
Volume10
Issue number3
DOIs
StatePublished - Apr 2012
Externally publishedYes

Keywords

  • Bacterial vaginosis
  • HIV
  • Inflammation
  • Trichomonas vaginalis

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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