The role of biotransformation in chemical induced liver injury

J. R. Mitchell, W. R. Snodgrass, J. R. Gillette

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The role of drug metabolism in chemical induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.

Original languageEnglish (US)
Pages (from-to)27-38
Number of pages12
JournalEnvironmental Health Perspectives
VolumeVol.15
StatePublished - 1976
Externally publishedYes

Fingerprint

biotransformation
Biotransformation
Metabolites
Liver
metabolite
Iproniazid
Isoniazid
Furosemide
Wounds and Injuries
toxicology
Acetaminophen
Metabolism
Toxicology
drug
metabolism
Pharmaceutical Preparations
chemical
bromobenzene
parameter

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Mitchell, J. R., Snodgrass, W. R., & Gillette, J. R. (1976). The role of biotransformation in chemical induced liver injury. Environmental Health Perspectives, Vol.15, 27-38.

The role of biotransformation in chemical induced liver injury. / Mitchell, J. R.; Snodgrass, W. R.; Gillette, J. R.

In: Environmental Health Perspectives, Vol. Vol.15, 1976, p. 27-38.

Research output: Contribution to journalArticle

Mitchell, JR, Snodgrass, WR & Gillette, JR 1976, 'The role of biotransformation in chemical induced liver injury', Environmental Health Perspectives, vol. Vol.15, pp. 27-38.
Mitchell, J. R. ; Snodgrass, W. R. ; Gillette, J. R. / The role of biotransformation in chemical induced liver injury. In: Environmental Health Perspectives. 1976 ; Vol. Vol.15. pp. 27-38.
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