The role of biotransformation in chemical induced liver injury

J. R. Mitchell, W. R. Snodgrass, J. R. Gillette

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The role of drug metabolism in chemical induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.

Original languageEnglish (US)
Pages (from-to)27-38
Number of pages12
JournalEnvironmental health perspectives
VolumeVol.15
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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    Mitchell, J. R., Snodgrass, W. R., & Gillette, J. R. (1976). The role of biotransformation in chemical induced liver injury. Environmental health perspectives, Vol.15, 27-38.