The role of biotransformation in chemical induced liver injury

J. R. Mitchell, W. R. Snodgrass, J. R. Gillette

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


The role of drug metabolism in chemical induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.

Original languageEnglish (US)
Pages (from-to)27-38
Number of pages12
JournalEnvironmental health perspectives
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'The role of biotransformation in chemical induced liver injury'. Together they form a unique fingerprint.

Cite this