The role of bone densitometry in the diagnosis and management of the severely burned patient with bone loss

Gordon L. Klein, David Herndon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Children and adults who suffer severe burn injuries develop abnormalities in bone and mineral metabolism. The most prominent of these is a reduction in bone formation. Events occurring immediately following burn injury that are likely contributors to the reduced bone formation include an increase in endogenous glucocorticoid production, functional growth hormone deficiency, hypoparathyroidism, and interoperative immobilization. The proinflammatory cytokines interleukin-1 β and interleukin-6 may also contribute. To date, the effects of burn injury on bone formation have been equivocal. However, the major reduction in bone formation without any consistent change in resorption suggests an uncoupling of formation and resorption. A consequence of this is lumbar spine bone loss as detected by dual-energy X-ray absorptiometry by 6 wk postburn. In both cross-sectional and longitudinal studies, the initial low bone density remains decreased in relation to unburned age-matched peers. The reduced bone density increases the risk for postburn fractures and for reduced peak bone mass, increasing the risk of these patients for adult-onset osteoporosis.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalJournal of Clinical Densitometry
Volume2
Issue number1
StatePublished - 1999

Fingerprint

Densitometry
Osteogenesis
Bone and Bones
Bone Density
Wounds and Injuries
Hypoparathyroidism
Photon Absorptiometry
Interleukin-1
Immobilization
Glucocorticoids
Growth Hormone
Osteoporosis
Minerals
Longitudinal Studies
Interleukin-6
Spine
Cross-Sectional Studies
Cytokines

Keywords

  • Bone loss
  • Burns
  • Glucocorticoids
  • Growth hormone
  • Hypoparathyroidism
  • Immobilization

ASJC Scopus subject areas

  • Medicine(all)
  • Radiology Nuclear Medicine and imaging

Cite this

The role of bone densitometry in the diagnosis and management of the severely burned patient with bone loss. / Klein, Gordon L.; Herndon, David.

In: Journal of Clinical Densitometry, Vol. 2, No. 1, 1999, p. 11-15.

Research output: Contribution to journalArticle

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