The role of connexin and pannexin containing channels in the innate and acquired immune response

Silvana Valdebenito, Andrea Barreto, Eliseo Eugenin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Connexin (Cx) and pannexin (Panx) containing channels – gap junctions (GJs) and hemichannels (HCs) – are present in virtually all cells and tissues. Currently, the role of these channels under physiological conditions is well defined. However, their role in the immune response and pathological conditions has only recently been explored. Data from several laboratories demonstrates that infectious agents, including HIV, have evolved to take advantage of GJs and HCs to improve viral/bacterial replication, enhance inflammation, and help spread toxicity into neighboring areas. In the current review, we discuss the role of Cx and Panx containing channels in immune activation and the pathogenesis of several infectious diseases. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve.

Original languageEnglish (US)
Pages (from-to)154-165
Number of pages12
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1860
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Connexins
Innate Immunity
Gap Junctions
Communicable Diseases
Toxicity
Chemical activation
HIV
Tissue
Inflammation

Keywords

  • Anti-retroviral
  • Apoptosis
  • Cure
  • NeuroAIDS
  • Reservoirs

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

Cite this

The role of connexin and pannexin containing channels in the innate and acquired immune response. / Valdebenito, Silvana; Barreto, Andrea; Eugenin, Eliseo.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1860, No. 1, 01.01.2018, p. 154-165.

Research output: Contribution to journalArticle

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