The role of costimulatory molecules in allergic disease and asthma

Vincent Lombardi, Abinav K. Singh, Omid Akbari

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The prevalence of allergic diseases has increased rapidly in recent years. It is well established that the deleterious allergic response is initiated by T-cell recognition of major histocompatibility class II-peptide complexes at the surface of antigen-presenting cells. While this first signal gives antigen specificity to the adaptive immune response, a second nonspecific costimulatory signal is required by T cells to become fully activated. This signal is provided by interactions between antigen-presenting cells and T cells through molecules borne at the surfaces of the two cell types. Depending on the type of molecules involved, this secondary signal can promote the development of an inflammatory allergic reaction or may favor immune regulation. Several molecules of the B7 family (CD80, CD86, PD-1, ICOS, CTLA-4) and tumor necrosis factor receptor family (OX40, CD30, 4-1BB, Fas, CD27, CD40) play an important role in delivering costimulatory signals in early and late phases of allergic response. Therefore, costimulatory molecules involved in promotion or prevention of allergic immune responses are potential targets for the development of novel therapeutic approaches. This review aims to recapitulate our current understanding of the relationship between allergic diseases and costimulatory molecules.

Original languageEnglish (US)
Pages (from-to)179-189
Number of pages11
JournalInternational Archives of Allergy and Immunology
Volume151
Issue number3
DOIs
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

Asthma
Antigen-Presenting Cells
T-Lymphocytes
B7 Antigens
Histocompatibility
Tumor Necrosis Factor Receptors
Adaptive Immunity
Surface Antigens
Hypersensitivity
Antigens
Peptides
Therapeutics

Keywords

  • Allergy
  • Asthma
  • Costimulatory molecules

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The role of costimulatory molecules in allergic disease and asthma. / Lombardi, Vincent; Singh, Abinav K.; Akbari, Omid.

In: International Archives of Allergy and Immunology, Vol. 151, No. 3, 02.2010, p. 179-189.

Research output: Contribution to journalArticle

Lombardi, Vincent ; Singh, Abinav K. ; Akbari, Omid. / The role of costimulatory molecules in allergic disease and asthma. In: International Archives of Allergy and Immunology. 2010 ; Vol. 151, No. 3. pp. 179-189.
@article{c465c3035d784b01aec0bef3187cbd4b,
title = "The role of costimulatory molecules in allergic disease and asthma",
abstract = "The prevalence of allergic diseases has increased rapidly in recent years. It is well established that the deleterious allergic response is initiated by T-cell recognition of major histocompatibility class II-peptide complexes at the surface of antigen-presenting cells. While this first signal gives antigen specificity to the adaptive immune response, a second nonspecific costimulatory signal is required by T cells to become fully activated. This signal is provided by interactions between antigen-presenting cells and T cells through molecules borne at the surfaces of the two cell types. Depending on the type of molecules involved, this secondary signal can promote the development of an inflammatory allergic reaction or may favor immune regulation. Several molecules of the B7 family (CD80, CD86, PD-1, ICOS, CTLA-4) and tumor necrosis factor receptor family (OX40, CD30, 4-1BB, Fas, CD27, CD40) play an important role in delivering costimulatory signals in early and late phases of allergic response. Therefore, costimulatory molecules involved in promotion or prevention of allergic immune responses are potential targets for the development of novel therapeutic approaches. This review aims to recapitulate our current understanding of the relationship between allergic diseases and costimulatory molecules.",
keywords = "Allergy, Asthma, Costimulatory molecules",
author = "Vincent Lombardi and Singh, {Abinav K.} and Omid Akbari",
year = "2010",
month = "2",
doi = "10.1159/000242355",
language = "English (US)",
volume = "151",
pages = "179--189",
journal = "International Archives of Allergy and Immunology",
issn = "1018-2438",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - The role of costimulatory molecules in allergic disease and asthma

AU - Lombardi, Vincent

AU - Singh, Abinav K.

AU - Akbari, Omid

PY - 2010/2

Y1 - 2010/2

N2 - The prevalence of allergic diseases has increased rapidly in recent years. It is well established that the deleterious allergic response is initiated by T-cell recognition of major histocompatibility class II-peptide complexes at the surface of antigen-presenting cells. While this first signal gives antigen specificity to the adaptive immune response, a second nonspecific costimulatory signal is required by T cells to become fully activated. This signal is provided by interactions between antigen-presenting cells and T cells through molecules borne at the surfaces of the two cell types. Depending on the type of molecules involved, this secondary signal can promote the development of an inflammatory allergic reaction or may favor immune regulation. Several molecules of the B7 family (CD80, CD86, PD-1, ICOS, CTLA-4) and tumor necrosis factor receptor family (OX40, CD30, 4-1BB, Fas, CD27, CD40) play an important role in delivering costimulatory signals in early and late phases of allergic response. Therefore, costimulatory molecules involved in promotion or prevention of allergic immune responses are potential targets for the development of novel therapeutic approaches. This review aims to recapitulate our current understanding of the relationship between allergic diseases and costimulatory molecules.

AB - The prevalence of allergic diseases has increased rapidly in recent years. It is well established that the deleterious allergic response is initiated by T-cell recognition of major histocompatibility class II-peptide complexes at the surface of antigen-presenting cells. While this first signal gives antigen specificity to the adaptive immune response, a second nonspecific costimulatory signal is required by T cells to become fully activated. This signal is provided by interactions between antigen-presenting cells and T cells through molecules borne at the surfaces of the two cell types. Depending on the type of molecules involved, this secondary signal can promote the development of an inflammatory allergic reaction or may favor immune regulation. Several molecules of the B7 family (CD80, CD86, PD-1, ICOS, CTLA-4) and tumor necrosis factor receptor family (OX40, CD30, 4-1BB, Fas, CD27, CD40) play an important role in delivering costimulatory signals in early and late phases of allergic response. Therefore, costimulatory molecules involved in promotion or prevention of allergic immune responses are potential targets for the development of novel therapeutic approaches. This review aims to recapitulate our current understanding of the relationship between allergic diseases and costimulatory molecules.

KW - Allergy

KW - Asthma

KW - Costimulatory molecules

UR - http://www.scopus.com/inward/record.url?scp=70349421440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349421440&partnerID=8YFLogxK

U2 - 10.1159/000242355

DO - 10.1159/000242355

M3 - Article

VL - 151

SP - 179

EP - 189

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 3

ER -