The role of endogenous prostaglandins in hormone-stimulated pancreatic exocrine secretion

R. Daniel Beauchamp, Donald G. MacLellan, James R. Upp, William H. Nealon, Courtney Townsend, James C. Thompson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The authors have previously shown that neurotensin and secretin inhibit gastric acid secretion in the dog and that these actions are inhibited by the prostaglandin synthesis inhibitor indomethacin. Conversely, neurotensin and secretin share similar stimulatory effects on pancreatic exocrine secretion. In the present study, the effects of blockade of prostaglandin synthesis by indomethacin on neurotensin-, cholecystokinin-, and secretin-stimulated exocrine secretion are examined along with the effects of these same agents on the release of pancreatic polypeptide. The studies were performed on conscious dogs with chronic gastric and pancreatic cannulas. Dose-dependent increases in pancreatic exocrine secretion of water and bicarbonate were observed with IV infusion of neurotensin or secretin; however, inhibition of prostaglandin synthesis by indomethacin abolished this response. Protein secretion stimulated by either neurotensin or cholecystokinin was not affected by prostaglandin inhibition. Cholecystokinin and neurotensin infusion stimulated release of pancreatic polypeptide; only neurotensin-stimulated release of pancreatic polypeptide was inhibited by indomethacin treatment. It is concluded that intact prostaglandin synthesis is necessary for the actions of neurotensin and secretin (but not that of cholecystokinin) on pancreatic exocrine secretion of water and bicarbonate and for neurotensin- (but not cholecystokinin-) stimulated release of pancreatic polypeptide.

Original languageEnglish (US)
Pages (from-to)272-279
Number of pages8
JournalGastroenterology
Volume102
Issue number1
StatePublished - 1992

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Pancreatic Hormones
Neurotensin
Prostaglandins
Secretin
Cholecystokinin
Pancreatic Polypeptide
Indomethacin
Bicarbonates
Dogs
Prostaglandin Antagonists
Water
Gastric Acid
Stomach

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Beauchamp, R. D., MacLellan, D. G., Upp, J. R., Nealon, W. H., Townsend, C., & Thompson, J. C. (1992). The role of endogenous prostaglandins in hormone-stimulated pancreatic exocrine secretion. Gastroenterology, 102(1), 272-279.

The role of endogenous prostaglandins in hormone-stimulated pancreatic exocrine secretion. / Beauchamp, R. Daniel; MacLellan, Donald G.; Upp, James R.; Nealon, William H.; Townsend, Courtney; Thompson, James C.

In: Gastroenterology, Vol. 102, No. 1, 1992, p. 272-279.

Research output: Contribution to journalArticle

Beauchamp, RD, MacLellan, DG, Upp, JR, Nealon, WH, Townsend, C & Thompson, JC 1992, 'The role of endogenous prostaglandins in hormone-stimulated pancreatic exocrine secretion', Gastroenterology, vol. 102, no. 1, pp. 272-279.
Beauchamp RD, MacLellan DG, Upp JR, Nealon WH, Townsend C, Thompson JC. The role of endogenous prostaglandins in hormone-stimulated pancreatic exocrine secretion. Gastroenterology. 1992;102(1):272-279.
Beauchamp, R. Daniel ; MacLellan, Donald G. ; Upp, James R. ; Nealon, William H. ; Townsend, Courtney ; Thompson, James C. / The role of endogenous prostaglandins in hormone-stimulated pancreatic exocrine secretion. In: Gastroenterology. 1992 ; Vol. 102, No. 1. pp. 272-279.
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