The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system

Eliseo Eugenin, Daniel Basilio, Juan C. Sáez, Juan A. Orellana, Cedric S. Raine, Feliksas Bukauskas, Michael V.L. Bennett, Joan W. Berman

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

Gap junctions (GJs) are expressed in most cell types of the nervous system, including neuronal stem cells, neurons, astrocytes, oligodendrocytes, cells of the blood brain barrier (endothelial cells and astrocytes) and under inflammatory conditions in microglia/macrophages. GJs connect cells by the docking of two hemichannels, one from each cell with each hemichannel being formed by 6 proteins named connexins (Cx). Unapposed hemichannels (uHC) also can be open on the surface of the cells allowing the release of different intracellular factors to the extracellular space. GJs provide a mechanism of cell-to-cell communication between adjacent cells that enables the direct exchange of intracellular messengers, such as calcium, nucleotides, IP3, and diverse metabolites, as well as electrical signals that ultimately coordinate tissue homeostasis, proliferation, differentiation, metabolism, cell survival and death. Despite their essential functions in physiological conditions, relatively little is known about the role of GJs and uHC in human diseases, especiallywithin the nervous system. The focus of this review is to summarize recent findings related to the role of GJs and uHC in physiologic and pathologic conditions of the central nervous system.

Original languageEnglish (US)
Pages (from-to)499-518
Number of pages20
JournalJournal of NeuroImmune Pharmacology
Volume7
Issue number3
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Fingerprint

Gap Junctions
Central Nervous System
Astrocytes
Connexins
Oligodendroglia
Extracellular Space
Microglia
Nervous System Diseases
Blood-Brain Barrier
Cell Communication
Nervous System
Cell Survival
Homeostasis
Cell Death
Stem Cells
Nucleotides
Endothelial Cells
Macrophages
Calcium
Neurons

Keywords

  • Alzheimer
  • Connexin
  • Disease
  • Hemichannels
  • HIV
  • NeuroAIDS

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. / Eugenin, Eliseo; Basilio, Daniel; Sáez, Juan C.; Orellana, Juan A.; Raine, Cedric S.; Bukauskas, Feliksas; Bennett, Michael V.L.; Berman, Joan W.

In: Journal of NeuroImmune Pharmacology, Vol. 7, No. 3, 01.09.2012, p. 499-518.

Research output: Contribution to journalReview article

Eugenin, Eliseo ; Basilio, Daniel ; Sáez, Juan C. ; Orellana, Juan A. ; Raine, Cedric S. ; Bukauskas, Feliksas ; Bennett, Michael V.L. ; Berman, Joan W. / The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. In: Journal of NeuroImmune Pharmacology. 2012 ; Vol. 7, No. 3. pp. 499-518.
@article{a7a3e4c49fec4aa6af89e0272b6b342f,
title = "The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system",
abstract = "Gap junctions (GJs) are expressed in most cell types of the nervous system, including neuronal stem cells, neurons, astrocytes, oligodendrocytes, cells of the blood brain barrier (endothelial cells and astrocytes) and under inflammatory conditions in microglia/macrophages. GJs connect cells by the docking of two hemichannels, one from each cell with each hemichannel being formed by 6 proteins named connexins (Cx). Unapposed hemichannels (uHC) also can be open on the surface of the cells allowing the release of different intracellular factors to the extracellular space. GJs provide a mechanism of cell-to-cell communication between adjacent cells that enables the direct exchange of intracellular messengers, such as calcium, nucleotides, IP3, and diverse metabolites, as well as electrical signals that ultimately coordinate tissue homeostasis, proliferation, differentiation, metabolism, cell survival and death. Despite their essential functions in physiological conditions, relatively little is known about the role of GJs and uHC in human diseases, especiallywithin the nervous system. The focus of this review is to summarize recent findings related to the role of GJs and uHC in physiologic and pathologic conditions of the central nervous system.",
keywords = "Alzheimer, Connexin, Disease, Hemichannels, HIV, NeuroAIDS",
author = "Eliseo Eugenin and Daniel Basilio and S{\'a}ez, {Juan C.} and Orellana, {Juan A.} and Raine, {Cedric S.} and Feliksas Bukauskas and Bennett, {Michael V.L.} and Berman, {Joan W.}",
year = "2012",
month = "9",
day = "1",
doi = "10.1007/s11481-012-9352-5",
language = "English (US)",
volume = "7",
pages = "499--518",
journal = "Journal of NeuroImmune Pharmacology",
issn = "1557-1890",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system

AU - Eugenin, Eliseo

AU - Basilio, Daniel

AU - Sáez, Juan C.

AU - Orellana, Juan A.

AU - Raine, Cedric S.

AU - Bukauskas, Feliksas

AU - Bennett, Michael V.L.

AU - Berman, Joan W.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Gap junctions (GJs) are expressed in most cell types of the nervous system, including neuronal stem cells, neurons, astrocytes, oligodendrocytes, cells of the blood brain barrier (endothelial cells and astrocytes) and under inflammatory conditions in microglia/macrophages. GJs connect cells by the docking of two hemichannels, one from each cell with each hemichannel being formed by 6 proteins named connexins (Cx). Unapposed hemichannels (uHC) also can be open on the surface of the cells allowing the release of different intracellular factors to the extracellular space. GJs provide a mechanism of cell-to-cell communication between adjacent cells that enables the direct exchange of intracellular messengers, such as calcium, nucleotides, IP3, and diverse metabolites, as well as electrical signals that ultimately coordinate tissue homeostasis, proliferation, differentiation, metabolism, cell survival and death. Despite their essential functions in physiological conditions, relatively little is known about the role of GJs and uHC in human diseases, especiallywithin the nervous system. The focus of this review is to summarize recent findings related to the role of GJs and uHC in physiologic and pathologic conditions of the central nervous system.

AB - Gap junctions (GJs) are expressed in most cell types of the nervous system, including neuronal stem cells, neurons, astrocytes, oligodendrocytes, cells of the blood brain barrier (endothelial cells and astrocytes) and under inflammatory conditions in microglia/macrophages. GJs connect cells by the docking of two hemichannels, one from each cell with each hemichannel being formed by 6 proteins named connexins (Cx). Unapposed hemichannels (uHC) also can be open on the surface of the cells allowing the release of different intracellular factors to the extracellular space. GJs provide a mechanism of cell-to-cell communication between adjacent cells that enables the direct exchange of intracellular messengers, such as calcium, nucleotides, IP3, and diverse metabolites, as well as electrical signals that ultimately coordinate tissue homeostasis, proliferation, differentiation, metabolism, cell survival and death. Despite their essential functions in physiological conditions, relatively little is known about the role of GJs and uHC in human diseases, especiallywithin the nervous system. The focus of this review is to summarize recent findings related to the role of GJs and uHC in physiologic and pathologic conditions of the central nervous system.

KW - Alzheimer

KW - Connexin

KW - Disease

KW - Hemichannels

KW - HIV

KW - NeuroAIDS

UR - http://www.scopus.com/inward/record.url?scp=84866064720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866064720&partnerID=8YFLogxK

U2 - 10.1007/s11481-012-9352-5

DO - 10.1007/s11481-012-9352-5

M3 - Review article

VL - 7

SP - 499

EP - 518

JO - Journal of NeuroImmune Pharmacology

JF - Journal of NeuroImmune Pharmacology

SN - 1557-1890

IS - 3

ER -