The role of gentamicin iontophoresis in the treatment of burned ears

M. H. Desai, R. L. Rutan, J. P. Heggers, M. I. Alvarado, K. McElroy, David Herndon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Ear cartilage heals slowly, and limited vascularity in cartilage precludes use of systemic antibiotics. Iontophoresis electrically induces drugs in solution to migrate into target tissues. Fifteen patients were randomized to receive gentamicin iontophoresis (n = 7) plus dressing changes every 6 hours and cleaning or routine care alone (n = 8) for treatment of ear burns. There were no differences between the groups in incidence of chondritis (43% vs 50%) or cartilage loss (11% vs 16%). However, gentamicin-resistant organisms developed in 29% of the patients who received iontophoresis, but in none of the patients in the control group (p < 0.05). To identify the etiology of the resistant organisms, 10 New Zealand white rabbits receive 7 cm2 contact burns to each ear. Gentamicin iontophoresis was performed on one ear, and the other ear served as the control. Serum gentamicin levels were always subtherapeutic. Additionally, gentamicin tissue levels in both the treated and control ears were subtherapeutic. Gentamicin iontophoresis appears to offer no additional salutary effects beyond those that are provided by routine care and may encourage the development of antibiotic resistance.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
JournalJournal of Burn Care and Rehabilitation
Volume12
Issue number6
StatePublished - 1991

Fingerprint

Iontophoresis
Gentamicins
Ear
Burns
Cartilage
Therapeutics
Ear Cartilage
Bandages
Microbial Drug Resistance
Anti-Bacterial Agents
Rabbits
Control Groups
Incidence
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery
  • Nursing(all)
  • Health Professions(all)

Cite this

Desai, M. H., Rutan, R. L., Heggers, J. P., Alvarado, M. I., McElroy, K., & Herndon, D. (1991). The role of gentamicin iontophoresis in the treatment of burned ears. Journal of Burn Care and Rehabilitation, 12(6), 521-524.

The role of gentamicin iontophoresis in the treatment of burned ears. / Desai, M. H.; Rutan, R. L.; Heggers, J. P.; Alvarado, M. I.; McElroy, K.; Herndon, David.

In: Journal of Burn Care and Rehabilitation, Vol. 12, No. 6, 1991, p. 521-524.

Research output: Contribution to journalArticle

Desai, MH, Rutan, RL, Heggers, JP, Alvarado, MI, McElroy, K & Herndon, D 1991, 'The role of gentamicin iontophoresis in the treatment of burned ears', Journal of Burn Care and Rehabilitation, vol. 12, no. 6, pp. 521-524.
Desai MH, Rutan RL, Heggers JP, Alvarado MI, McElroy K, Herndon D. The role of gentamicin iontophoresis in the treatment of burned ears. Journal of Burn Care and Rehabilitation. 1991;12(6):521-524.
Desai, M. H. ; Rutan, R. L. ; Heggers, J. P. ; Alvarado, M. I. ; McElroy, K. ; Herndon, David. / The role of gentamicin iontophoresis in the treatment of burned ears. In: Journal of Burn Care and Rehabilitation. 1991 ; Vol. 12, No. 6. pp. 521-524.
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