The role of H<inf>2</inf>S bioavailability in endothelial dysfunction

Rui Wang, Csaba Szabo, Fumito Ichinose, Asif Ahmed, Matthew Whiteman, Andreas Papapetropoulos

    Research output: Contribution to journalArticle

    65 Citations (Scopus)

    Abstract

    Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H<inf>2</inf>S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H<inf>2</inf>S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H<inf>2</inf>S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H<inf>2</inf>S bioavailability may benefit all.

    Original languageEnglish (US)
    Pages (from-to)568-578
    Number of pages11
    JournalTrends in Pharmacological Sciences
    Volume36
    Issue number9
    DOIs
    StatePublished - Sep 12 2015

    Fingerprint

    Endothelial cells
    Biological Availability
    Endothelial Cells
    Hydrogen Sulfide
    Pathology
    Cardiovascular Diseases
    Phenotype
    Research
    Therapeutics

    Keywords

    • cystathionine gamma-lyase
    • endothelium-derived hyperpolarizing factor
    • gasotransmitters
    • heme oxygenase-1
    • hydrogen sulfide
    • nitric oxide

    ASJC Scopus subject areas

    • Pharmacology
    • Toxicology

    Cite this

    The role of H<inf>2</inf>S bioavailability in endothelial dysfunction. / Wang, Rui; Szabo, Csaba; Ichinose, Fumito; Ahmed, Asif; Whiteman, Matthew; Papapetropoulos, Andreas.

    In: Trends in Pharmacological Sciences, Vol. 36, No. 9, 12.09.2015, p. 568-578.

    Research output: Contribution to journalArticle

    Wang, Rui ; Szabo, Csaba ; Ichinose, Fumito ; Ahmed, Asif ; Whiteman, Matthew ; Papapetropoulos, Andreas. / The role of H<inf>2</inf>S bioavailability in endothelial dysfunction. In: Trends in Pharmacological Sciences. 2015 ; Vol. 36, No. 9. pp. 568-578.
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