The role of H<inf>2</inf>S bioavailability in endothelial dysfunction

Rui Wang, Csaba Szabo, Fumito Ichinose, Asif Ahmed, Matthew Whiteman, Andreas Papapetropoulos

    Research output: Contribution to journalArticlepeer-review

    79 Scopus citations

    Abstract

    Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H<inf>2</inf>S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H<inf>2</inf>S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H<inf>2</inf>S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H<inf>2</inf>S bioavailability may benefit all.

    Original languageEnglish (US)
    Pages (from-to)568-578
    Number of pages11
    JournalTrends in Pharmacological Sciences
    Volume36
    Issue number9
    DOIs
    StatePublished - Sep 12 2015

    Keywords

    • cystathionine gamma-lyase
    • endothelium-derived hyperpolarizing factor
    • gasotransmitters
    • heme oxygenase-1
    • hydrogen sulfide
    • nitric oxide

    ASJC Scopus subject areas

    • Pharmacology
    • Toxicology

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