@article{47155bda146f4ecf99cb01073ee37b0e,
title = "The role of H2S bioavailability in endothelial dysfunction",
abstract = "Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H2S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H2S bioavailability may benefit all.",
keywords = "cystathionine gamma-lyase, endothelium-derived hyperpolarizing factor, gasotransmitters, heme oxygenase-1, hydrogen sulfide, nitric oxide",
author = "Rui Wang and Csaba Szabo and Fumito Ichinose and Asif Ahmed and Matthew Whiteman and Andreas Papapetropoulos",
note = "Funding Information: This work has been supported by a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC) to R.W. C.S. has been supported by the American Diabetes Association, the US National Institutes of Health (NIH), and the Shriners Hospitals for Children. F.I. has been supported by the NIH. MW has been supported by the UK Medical Research Council (MRC). A.A. has been supported by program grants from the British Heart Foundation (RG/09/001/25940), MRC (G0700288), Royal Society, and the European Commission. A.P. has been supported through an Aristeia grant (1436) that is co-financed by the European Commission (ESF) and Greek national funds through the Operational Program {\textquoteleft}Education and Lifelong Learning{\textquoteright}. M.W. and A.P. are supported by the COST (Cooperation in Science and Technology) Action BM1005 (ENOG: European Network on Gasotransmitters). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = sep,
day = "12",
doi = "10.1016/j.tips.2015.05.007",
language = "English (US)",
volume = "36",
pages = "568--578",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "9",
}