The role of H2S bioavailability in endothelial dysfunction

Rui Wang; Csaba Szabo; Fumito Ichinose; Asif Ahmed; Matthew Whiteman; Andreas Papapetropoulos

doi:10.1016/j.tips.2015.05.007

The role of H₂S bioavailability in endothelial dysfunction

Rui Wang, Csaba Szabo, Fumito Ichinose, Asif Ahmed, Matthew Whiteman, Andreas Papapetropoulos

Surgery

Research output: Contribution to journal › Review article › peer-review

142 Scopus citations

Abstract

Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H₂S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H₂S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H₂S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H₂S bioavailability may benefit all.

Original language	English (US)
Pages (from-to)	568-578
Number of pages	11
Journal	Trends in Pharmacological Sciences
Volume	36
Issue number	9
DOIs	https://doi.org/10.1016/j.tips.2015.05.007
State	Published - Sep 12 2015

Keywords

cystathionine gamma-lyase
endothelium-derived hyperpolarizing factor
gasotransmitters
heme oxygenase-1
hydrogen sulfide
nitric oxide

ASJC Scopus subject areas

Toxicology
Pharmacology

Access to Document

10.1016/j.tips.2015.05.007

Cite this

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title = "The role of H2S bioavailability in endothelial dysfunction",

abstract = "Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H2S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H2S bioavailability may benefit all.",

keywords = "cystathionine gamma-lyase, endothelium-derived hyperpolarizing factor, gasotransmitters, heme oxygenase-1, hydrogen sulfide, nitric oxide",

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AU - Wang, Rui

AU - Szabo, Csaba

AU - Ichinose, Fumito

AU - Ahmed, Asif

AU - Whiteman, Matthew

AU - Papapetropoulos, Andreas

PY - 2015/9/12

Y1 - 2015/9/12

N2 - Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H2S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H2S bioavailability may benefit all.

AB - Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H2S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H2S bioavailability may benefit all.

KW - cystathionine gamma-lyase

KW - endothelium-derived hyperpolarizing factor

KW - gasotransmitters

KW - heme oxygenase-1

KW - hydrogen sulfide

KW - nitric oxide

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