The role of H2S bioavailability in endothelial dysfunction

Rui Wang, Csaba Szabo, Fumito Ichinose, Asif Ahmed, Matthew Whiteman, Andreas Papapetropoulos

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations

Abstract

Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H2S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H2S bioavailability may benefit all.

Original languageEnglish (US)
Pages (from-to)568-578
Number of pages11
JournalTrends in Pharmacological Sciences
Volume36
Issue number9
DOIs
StatePublished - Sep 12 2015
Externally publishedYes

Keywords

  • cystathionine gamma-lyase
  • endothelium-derived hyperpolarizing factor
  • gasotransmitters
  • heme oxygenase-1
  • hydrogen sulfide
  • nitric oxide

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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