The role of human decay-accelerating factor in the pathogenesis of preterm labor

Luis Pacheco, Gary Hankins, Maged Costantine, Garland D. Anderson, Edyta Pawelczyk, Stella Nowicki, Bogdan J. Nowicki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Complement activation is thought to contribute to the pathogenesis of preterm labor (PTL). Decay-accelerating factor (DAF) is a natural complement pathway inhibitor. Our hypothesis was that DAF expression on maternal white blood cells (WBCs) in women with preterm labor is elevated compared with women with no preterm labor. Our secondary objective was to determine if differences in upregulation of DAF levels correlated with clinical outcomes. Serial blood samples were obtained from 30 patients with a clinical diagnosis of PTL and a control group of 30 pregnant individuals (same gestational age range) to determine DAF expression in peripheral WBCs in both groups. DAF expression was higher in women with PTL (less than 37 weeks) compared with the control group without PTL. Subjects with PTL who delivered before 34 weeks had less DAF expression and different kinetics of expression compared with those carrying pregnancies beyond 34 weeks. These data suggest that women with a clinical diagnosis of preterm labor have increased DAF expression on peripheral WBCs. Furthermore, it appears that failure to elevate DAF expression is associated with a risk of early premature delivery.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalAmerican Journal of Perinatology
Volume28
Issue number7
DOIs
StatePublished - 2011

Fingerprint

CD55 Antigens
Premature Obstetric Labor
Leukocytes
Complement Inactivating Agents
Control Groups
Complement Activation
Gestational Age
Up-Regulation
Mothers
Pregnancy

Keywords

  • complement activation
  • decay-accelerating factor
  • Preterm labor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Pacheco, L., Hankins, G., Costantine, M., Anderson, G. D., Pawelczyk, E., Nowicki, S., & Nowicki, B. J. (2011). The role of human decay-accelerating factor in the pathogenesis of preterm labor. American Journal of Perinatology, 28(7), 565-570. https://doi.org/10.1055/s-0031-1274510

The role of human decay-accelerating factor in the pathogenesis of preterm labor. / Pacheco, Luis; Hankins, Gary; Costantine, Maged; Anderson, Garland D.; Pawelczyk, Edyta; Nowicki, Stella; Nowicki, Bogdan J.

In: American Journal of Perinatology, Vol. 28, No. 7, 2011, p. 565-570.

Research output: Contribution to journalArticle

Pacheco, L, Hankins, G, Costantine, M, Anderson, GD, Pawelczyk, E, Nowicki, S & Nowicki, BJ 2011, 'The role of human decay-accelerating factor in the pathogenesis of preterm labor', American Journal of Perinatology, vol. 28, no. 7, pp. 565-570. https://doi.org/10.1055/s-0031-1274510
Pacheco, Luis ; Hankins, Gary ; Costantine, Maged ; Anderson, Garland D. ; Pawelczyk, Edyta ; Nowicki, Stella ; Nowicki, Bogdan J. / The role of human decay-accelerating factor in the pathogenesis of preterm labor. In: American Journal of Perinatology. 2011 ; Vol. 28, No. 7. pp. 565-570.
@article{b84e9b80bd4f4a8abe7d6eef06a4a11e,
title = "The role of human decay-accelerating factor in the pathogenesis of preterm labor",
abstract = "Complement activation is thought to contribute to the pathogenesis of preterm labor (PTL). Decay-accelerating factor (DAF) is a natural complement pathway inhibitor. Our hypothesis was that DAF expression on maternal white blood cells (WBCs) in women with preterm labor is elevated compared with women with no preterm labor. Our secondary objective was to determine if differences in upregulation of DAF levels correlated with clinical outcomes. Serial blood samples were obtained from 30 patients with a clinical diagnosis of PTL and a control group of 30 pregnant individuals (same gestational age range) to determine DAF expression in peripheral WBCs in both groups. DAF expression was higher in women with PTL (less than 37 weeks) compared with the control group without PTL. Subjects with PTL who delivered before 34 weeks had less DAF expression and different kinetics of expression compared with those carrying pregnancies beyond 34 weeks. These data suggest that women with a clinical diagnosis of preterm labor have increased DAF expression on peripheral WBCs. Furthermore, it appears that failure to elevate DAF expression is associated with a risk of early premature delivery.",
keywords = "complement activation, decay-accelerating factor, Preterm labor",
author = "Luis Pacheco and Gary Hankins and Maged Costantine and Anderson, {Garland D.} and Edyta Pawelczyk and Stella Nowicki and Nowicki, {Bogdan J.}",
year = "2011",
doi = "10.1055/s-0031-1274510",
language = "English (US)",
volume = "28",
pages = "565--570",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers",
number = "7",

}

TY - JOUR

T1 - The role of human decay-accelerating factor in the pathogenesis of preterm labor

AU - Pacheco, Luis

AU - Hankins, Gary

AU - Costantine, Maged

AU - Anderson, Garland D.

AU - Pawelczyk, Edyta

AU - Nowicki, Stella

AU - Nowicki, Bogdan J.

PY - 2011

Y1 - 2011

N2 - Complement activation is thought to contribute to the pathogenesis of preterm labor (PTL). Decay-accelerating factor (DAF) is a natural complement pathway inhibitor. Our hypothesis was that DAF expression on maternal white blood cells (WBCs) in women with preterm labor is elevated compared with women with no preterm labor. Our secondary objective was to determine if differences in upregulation of DAF levels correlated with clinical outcomes. Serial blood samples were obtained from 30 patients with a clinical diagnosis of PTL and a control group of 30 pregnant individuals (same gestational age range) to determine DAF expression in peripheral WBCs in both groups. DAF expression was higher in women with PTL (less than 37 weeks) compared with the control group without PTL. Subjects with PTL who delivered before 34 weeks had less DAF expression and different kinetics of expression compared with those carrying pregnancies beyond 34 weeks. These data suggest that women with a clinical diagnosis of preterm labor have increased DAF expression on peripheral WBCs. Furthermore, it appears that failure to elevate DAF expression is associated with a risk of early premature delivery.

AB - Complement activation is thought to contribute to the pathogenesis of preterm labor (PTL). Decay-accelerating factor (DAF) is a natural complement pathway inhibitor. Our hypothesis was that DAF expression on maternal white blood cells (WBCs) in women with preterm labor is elevated compared with women with no preterm labor. Our secondary objective was to determine if differences in upregulation of DAF levels correlated with clinical outcomes. Serial blood samples were obtained from 30 patients with a clinical diagnosis of PTL and a control group of 30 pregnant individuals (same gestational age range) to determine DAF expression in peripheral WBCs in both groups. DAF expression was higher in women with PTL (less than 37 weeks) compared with the control group without PTL. Subjects with PTL who delivered before 34 weeks had less DAF expression and different kinetics of expression compared with those carrying pregnancies beyond 34 weeks. These data suggest that women with a clinical diagnosis of preterm labor have increased DAF expression on peripheral WBCs. Furthermore, it appears that failure to elevate DAF expression is associated with a risk of early premature delivery.

KW - complement activation

KW - decay-accelerating factor

KW - Preterm labor

UR - http://www.scopus.com/inward/record.url?scp=79960836834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960836834&partnerID=8YFLogxK

U2 - 10.1055/s-0031-1274510

DO - 10.1055/s-0031-1274510

M3 - Article

C2 - 21380985

AN - SCOPUS:79960836834

VL - 28

SP - 565

EP - 570

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

IS - 7

ER -