The role of hyperglycemia in burned patients: Evidence-based studies

Gabriel A. Mecott, Ahmed M. Al-Mousawi, Gerd G. Gauglitz, David Herndon, Marc G. Jeschke

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Severely burned patients typically experience a systemic response expressed as increased metabolism, inflammation, alteration of cardiac and immune function, and associated hyperglycemia. Hyperglycemia has been associated with an increased risk of morbidity and mortality in critically ill patients. Until recently and for many years, hyperglycemia has been expectantly managed and considered a normal and desired response of an organism to stress. However, findings reported from recent studies now suggest beneficial effects of intensive insulin treatment of critically ill patients. The literature on the management of hyperglycemia in severely burned patients is sparse, with most of the available studies involving only small numbers of burned patients. The purpose of this article is to describe the pathophysiology of hyperglycemia after severe burns and to review the available literature on the outcome of intensive insulin treatment and other anti-hyperglycemic modalities in burned patients in an evidence-based medical approach.

Original languageEnglish (US)
Pages (from-to)5-13
Number of pages9
JournalShock
Volume33
Issue number1
DOIs
StatePublished - Jan 2010

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Keywords

  • Burns
  • Fenofibrate
  • Glucose modulation
  • Intensive insulin
  • Metformin

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Mecott, G. A., Al-Mousawi, A. M., Gauglitz, G. G., Herndon, D., & Jeschke, M. G. (2010). The role of hyperglycemia in burned patients: Evidence-based studies. Shock, 33(1), 5-13. https://doi.org/10.1097/SHK.0b013e3181af0494